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Japanese Society for Palliative Medicine
News Letter No.93
日本緩和医療学会ニューズレター
Nov 2021  93
Journal Watch
緩和ケアに関する論文レビュー
名古屋大学大学院医学系研究科 総合保健学専攻高度実践看護開発学講座
川島 有沙

対象雑誌:N Engl J Med, Lancet, Lancet Oncol, JAMA, JAMA Intern Med, JAMA Oncol, BMJ, Ann Intern Med, J Clin Oncol, Ann Oncol, Eur J Cancer, Br J Cancer, Cancer

対象期間:2021年6月〜8月刊行分

いわゆる“トップジャーナル”に掲載された緩和ケアに関する最新論文を広く紹介します。


【N Engl J Med. 2021;384(22-25),385(1-9)】
なし

【Lancet. 2021;397(10290-10293),398(10294-10302)】
1. 不安障害に対するベンゾジアゼピン系薬剤の不適切な長期使用
Tibrewal P, Looi JCL, Allison S, Bastiampillai T. Benzodiazepines for the long-term treatment of anxiety disorders? Lancet. 2021;398(10295):119-20. [PMID: 34246344]

【Lancet Oncol.2021;22(6-8)】
2. 痛みを伴う脊椎転移に対する脊椎定位放射線治療の無作為化比較試験
Sahgal A, Myrehaug SD, Siva S, Masucci GL, Maralani PJ, Brundage M, et al. Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial. Lancet Oncol. 2021;22(7):1023-33. [PMID: 34126044]
3. ヘルスケアアプリ使用の有無で比較した開業医と外科医によるがんサバイバーシップケアのQOLへの効果に関する無作為化試験の中間解析
Vos JAM, Duineveld LAM, Wieldraaijer T, Wind J, Busschers WB, Sert E, et al. Effect of general practitioner-led versus surgeon-led colon cancer survivorship care, with or without eHealth support, on quality of life (I CARE): an interim analysis of 1-year results of a randomised, controlled trial. Lancet Oncol. 2021;22(8):1175-87. [PMID: 34224671]

【JAMA. 2021;325(21-24), 326(1-8)】
4. 重篤患者の代理意思決定者への支援方法を見直す
Dionne-Odom JN, White DB. Reconceptualizing How to Support Surrogates Making Medical Decisions for Critically Ill Patients. JAMA. 2021;325(21):2147-8. [PMID: 33988689]
5. 非がん慢性疼痛患者へのオピオイド鎮痛薬漸減による過量投与や精神的危機との関連
Agnoli A, Xing G, Tancredi DJ, Magnan E, Jerant A, Fenton JJ. Association of Dose Tapering With Overdose or Mental Health Crisis Among Patients Prescribed Long-term Opioids. JAMA. 2021;326(5):411-9. [PMID: 34342618]

【JAMA Intern Med. 2021;181(6-8)】
6. Time-Limited Trialで無益な治療を減らせるか
Chang DW, Neville TH, Parrish J, Ewing L, Rico C, Jara L, et al. Evaluation of Time-Limited Trials Among Critically Ill Patients With Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments. JAMA Intern Med. 2021;181(6):786-94. [PMID: 33843946]
7. 支持療法の試験で死亡率をアウトカムにすることの問題点
Halpern SD, Temel JS, Courtright KR. Dealing With Death as an Outcome in Supportive Care Clinical Trials. JAMA Intern Med. 2021;181(7):895-6. [PMID: 33970194]
8. ホスピス経営の問題がケアの質に与える影響
Aldridge MD. Hospice Tax Status and Ownership Matters for Patients and Families. JAMA Intern Med. 2021;181(8):1114-5. [PMID: 33938916]

【JAMA Oncol. 2021;7(6-8)】
9. COVID-19禍での患者への付添い
Jacobson JO. Accompanying Patients in the Time of COVID-19. JAMA Oncol. 2021;7(7):971-2.[PMID: 34014248]
10. 乳がん患者のCOVID-19ワクチンへの躊躇と関連する因子
Villarreal-Garza C, Vaca-Cartagena BF, Becerril-Gaitan A, Ferrigno AS, Mesa-Chavez F, Platas A, et al. Attitudes and Factors Associated With COVID-19 Vaccine Hesitancy Among Patients With Breast Cancer. JAMA Oncol. 2021;7(8):1242-4. [PMID: 34110371]

【BMJ. 2020;373(8294-8297), 374(8298-8303)】
11. 化学療法中の遠隔症状モニタリングの欧州多施設無作為化比較試験
Maguire R, McCann L, Kotronoulas G, Kearney N, Ream E, Armes J, et al. Real time remote symptom monitoring during chemotherapy for cancer: European multicentre randomised controlled trial (eSMART). BMJ. 2021;374:n1647. [PMID: 34289996]

【Ann Intern Med. 2021;174(6-8)】
なし

【J Clin Oncol. 2021;39(16-24)】
12. 標準治療として介護者情報記録を作成することの提案
Applebaum AJ, Kent EE, Lichtenthal WG. Documentation of Caregivers as a Standard of Care. J Clin Oncol. 2021;39(18):1955-8. [PMID: 33945287]
13. 小児がんにおける神経認知機能の評価とモニタリング
Jacola LM, Partanen M, Lemiere J, Hudson MM, Thomas S. Assessment and Monitoring of Neurocognitive Function in Pediatric Cancer. J Clin Oncol. 2021;39(16):1696-704. [PMID: 33886364]
14. 小児がんサバイバーの認知障害と家族機能の関連についての系統的レビュー
Schepers SA, Schulte FSM, Patel SK, Vannatta K. Cognitive Impairment and Family Functioning of Survivors of Pediatric Cancer: A Systematic Review. J Clin Oncol. 2021;39(16):1795-812. [PMID: 33886349]
15. 小児がんサバイバーの老化と将来のケア
Schuitema I, Alexander T, Hudson MM, Krull KR, Edelstein K. Aging in Adult Survivors of Childhood Cancer: Implications for Future Care. J Clin Oncol. 2021;39(16):1741-51. [PMID: 33886351]
16. 小児がんサバイバーの神経認知的晩期障害に対するアプローチ
Hocking MC, Walsh KS, Hardy KK, Conklin HM. Addressing Neurocognitive Late Effects in Pediatric Cancer Survivors: Current Approaches and Future Opportunities. J Clin Oncol. 2021;39(16):1824-32. [PMID: 33886353]
17. 小児がんサバイバーへの教育支援の系統的レビュー
Gilleland Marchak J, Devine KA, Hudson MM, Jacobson LA, Michel G, Peterson SR, et al. Systematic Review of Educational Supports of Pediatric Cancer Survivors: Current Approaches and Future Directions. J Clin Oncol. 2021;39(16):1813-23. [PMID: 33886350]
18. 緩和ケアがAYA世代のがんの終末期ケアに及ぼす影響についての人口ベースのコホート研究
Kassam A, Gupta A, Rapoport A, Srikanthan A, Sutradhar R, Luo J, et al. Impact of Palliative Care Involvement on End-of-Life Care Patterns Among Adolescents and Young Adults With Cancer: A Population-Based Cohort Study. J Clin Oncol. 2021;39(22):2506-15. [PMID: 34097441]
19. 在宅で入院治療と同程度のがんケアを行うHospital-at-home (HaH)の予定外医療利用と医療費の評価
Mooney K, Titchener K, Haaland B, Coombs LA, O'Neil B, Nelson R, et al. Evaluation of Oncology Hospital at Home: Unplanned Health Care Utilization and Costs in the Huntsman at Home Real-World Trial. J Clin Oncol. 2021;39(23):2586-93. [PMID: 33999660]

【Ann Oncol. 2021;32(6-8)】
20. オマリズマブで免疫チェックポイント阻害薬および抗HER2薬の掻痒が改善
Barrios DM, Phillips GS, Geisler AN, Trelles SR, Markova A, Noor SJ, et al. IgE blockade with omalizumab reduces pruritus related to immune checkpoint inhibitors and anti-HER2 therapies. Ann Oncol. 2021;32(6):736-45. [PMID: 33667669]
21. 入院患者への栄養サポートはがん種に関わらず死亡率を低下させる
Bargetzi L, Brack C, Herrmann J, Bargetzi A, Hersberger L, Bargetzi M, et al. Nutritional support during the hospital stay reduces mortality in patients with different types of cancers: secondary analysis of a prospective randomized trial. Ann Oncol. 2021;32(8):1025-33. [PMID: 34022376]

【Eur J Cancer. 2021;150-153】
22. 小児がんサバイバーの健康関連QOLについての全国コホート研究
van Erp LME, Maurice-Stam H, Kremer LCM, Tissing WJE, van der Pal HJH, de Vries ACH, et al. Health-related quality of life in Dutch adult survivors of childhood cancer: A nation-wide cohort study. Eur J Cancer. 2021;152:204-14. [PMID: 34119924]
23.小児がん臨床試験における患者報告型アウトカムの稀な使用に関する系統的レビュー
Riedl D, Rothmund M, Darlington AS, Sodergren S, Crazzolara R, de Rojas T, et al. Rare use of patient-reported outcomes in childhood cancer clinical trials - a systematic review of clinical trial registries. Eur J Cancer. 2021;152:90-9. [PMID: 34090144]

【Br J Cancer. 2021;124(12), 125(1-4)】
24. 大腸がん化学療法を受ける虚弱高齢者への老年機能評価に基づく介入の無作為化比較試験
Lund CM, Vistisen KK, Olsen AP, Bardal P, Schultz M, Dolin TG, et al. The effect of geriatric intervention in frail older patients receiving chemotherapy for colorectal cancer: a randomised trial (GERICO). Br J Cancer. 2021;124(12):1949-58. [PMID: 33828260]
25. 早期乳がんサバイバーの末梢神経障害の危険因子に関するコホート研究
Engvall K, Green H, Fredriksson M, Avall-Lundqvist E. Persistent neuropathy among early-stage breast cancer survivors in a population-based cohort. Br J Cancer. 2021;125(3):445-57. [PMID: 34017086]

【Cancer. 2021;127(11-16)】
26. がんAYA世代と介護者用の経済負担評価指標と有用性についてのレビュー
Salsman JM, Danhauer SC, Moore JB, Ip EH, McLouth LE, Nightingale CL, et al. Systematic review of financial burden assessment in cancer: Evaluation of measures and utility among adolescents and young adults and caregivers. Cancer. 2021;127(11):1739-48. [PMID: 33849081]
27. アジア人女性の乳がん予後予測モデルの開発
Fan R, Chen Y, Nechuta S, Cai H, Gu K, Shi L, et al. Prediction models for breast cancer prognosis among Asian women. Cancer. 2021;127(11):1758-69. [PMID: 33704778]
28. 高齢のアフリカ系アメリカ人乳がんサバイバーを運動介入RCTに組み入れるための戦略の検討
Owusu C, Nock NL, Feuntes V, Margevicius S, Hergenroeder P, Austin K, et al. IMPROVE, a community-based exercise intervention versus support group to improve functional and health outcomes among older African American and Non-Hispanic White breast cancer survivors from diverse socioeconomic backgrounds: Recruitment strategies and baseline characteristics. Cancer. 2021;127(11):1836-46. [PMID: 33539554]
29. 急性リンパ性白血病の若年成人における医療機関での支出額の違い
Wolfson JA, Bhatia S, Ginsberg J, Becker LK, Bernstein D, Henk HJ, et al. Expenditures among young adults with acute lymphoblastic leukemia by site of care. Cancer. 2021;127(11):1901-11. [PMID: 33465248]
30. 進行がん臨床試験の同意文により緩和ケアの価値を下げていないか(コメンタリー)
Umaretiya PJ, Rubin JP, Snaman JM, Ullrich C, Feraco AM, Dussel V, et al. Are we undermining the value of palliative care through advanced cancer clinical trial consent language? Cancer. 2021;127(12):1954-6. [PMID: 33689176]
31. 乳がん手術を受けた保険加入患者における破産のリスク因子
Obeng-Gyasi S, Timsina LR, Bhattacharyya O, Fisher CS, Haggstrom DA. Bankruptcy among insured surgical patients with breast cancer: Who is at risk? Cancer. 2021;127(12):2083-90. [PMID: 33606915]
32.小児腫瘍学におけるコミュニケーションの障壁についての臨床家の視点
Sisk BA, Friedrich AB, Kaye EC, Baker JN, Mack JW, DuBois JM. Multilevel barriers to communication in pediatric oncology: Clinicians' perspectives. Cancer. 2021;127(12):2130-8. [PMID: 33598930]
33. 米国のがんセンターにおける緩和ケア教育と研究の全国調査
Hui D, De La Rosa A, Chen J, Delgado Guay M, Heung Y, Dibaj S, et al. Palliative care education and research at US cancer centers: A national survey. Cancer. 2021;127(12):2139-47. [PMID: 33662148]
34. 緩和ケアと腫瘍学の統合の確立と未来(エディトリアル)
Jan MY, Campbell TC. The establishment and future of integrated onco-palliative care. Cancer. 2021;127(12):1963-4. [PMID: 33662141]
35. 卵巣がん女性の積極的な終末期医療の傾向と人種格差についてのデータベース研究
Mullins MA, Ruterbusch JJ, Clarke P, Uppal S, Wallner LP, Cote ML. Trends and racial disparities in aggressive end-of-life care for a national sample of women with ovarian cancer. Cancer. 2021;127(13):2229-37. [PMID: 33631053]
36. 治療を開始した乳がん患者のQOL評価のためのPatient-Reported Outcomes Measurement Information System(PROMIS)の導入
Matthys MB, Dempsey AM, Melisko ME, Dreher N, Che ML, Van't Veer LJ, et al. Incorporation of Patient-Reported Outcomes Measurement Information System to assess quality of life among patients with breast cancer initiating care at an academic center. Cancer. 2021;127(13):2342-9. [PMID: 33957704]
37. ドイツ・バイエルン州の農村部と都市部の乳がん治療施設へのアクセスの格差
Stangl S, Rauch S, Rauh J, Meyer M, Muller-Nordhorn J, Wildner M, et al. Disparities in accessibility to evidence-based breast cancer care facilities by rural and urban areas in Bavaria, Germany. Cancer. 2021;127(13):2319-32. [PMID: 33826747]
38. 急性骨髄性白血病患者における心的外傷後ストレス障害の症状
Amonoo HL, LeBlanc TW, Kavanaugh AR, Webb JA, Traeger LN, Jagielo AD, et al. Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia. Cancer. 2021;127(14):2500-6. [PMID: 33764526]
39. 黒人男性と白人男性の前立腺がん患者の死亡率の推移と人種・社会経済的地位の格差の関連
Iyer HS, Gomez SL, Chen JT, Trinh QD, Rebbeck TR. Trends in mortality among Black and White men with prostate cancer in Massachusetts and Pennsylvania: Race and neighborhood socioeconomic position. Cancer. 2021;127(14):2525-34. [PMID: 33798264]
40. 救外からの入院を要するがん患者のがん種とアウトカムについての人口ベースの研究
Kim YJ, Seo DW, Kim WY. Types of cancer and outcomes in patients with cancer requiring admission from the emergency department: A nationwide, population-based study, 2016-2017. Cancer. 2021;127(14):2553-61. [PMID: 33740270]
41. 修正デルファイ法による小児がん終末期ケアの質指標の評価
Johnston EE, Martinez I, Wolfe J, Asch SM. Quality measures for end-of-life care for children with cancer: A modified Delphi approach. Cancer. 2021;127(14):2571-8. [PMID: 33784408]
42. 腫瘍内科医への補完代替療法に関する教育の患者報告型アウトカムへの効果についての多施設クラスター無作為化試験
Rogge AA, Helmer SM, King R, Canella C, Icke K, Pach D, et al. Effects of training oncology physicians advising patients on complementary and integrative therapies on patient-reported outcomes: A multicenter, cluster-randomized trial. Cancer. 2021;127(15):2683-92. [PMID: 33905536]
43. 成人の小児がんサバイバーにおけるがん関連の心配の予測因子と健康行動との関連
McDonnell GA, Brinkman TM, Wang M, Gibson TM, Heathcote LC, Ehrhardt MJ, et al. Prevalence and predictors of cancer-related worry and associations with health behaviors in adult survivors of childhood cancer. Cancer. 2021;127(15):2743-51. [PMID: 33844273]
44. インフォーマルな介護者を持つ米国のがんサバイバーの特徴
Borsky AE, Zuvekas SH, Kent EE, de Moor JS, Ngo-Metzger Q, Soni A. Understanding the characteristics of US cancer survivors with informal caregivers. Cancer. 2021;127(15):2752-61. [PMID: 33945632]
45. 乳がんサバイバーの不健康行動とリスク因子
Di Meglio A, Gbenou AS, Martin E, Pistilli B, Ligibel JA, Crane TE, et al. Unhealthy behaviors after breast cancer: Capitalizing on a teachable moment to promote lifestyle improvements. Cancer. 2021;127(15):2774-87. [PMID: 33887074]
46. 化学療法目的で入院した小児がん患者における電子的症状モニタリング
Leahy AB, Schwartz LA, Li Y, Reeve BB, Bekelman JE, Aplenc R, et al. Electronic symptom monitoring in pediatric patients hospitalized for chemotherapy. Cancer. 2021;127(16):2980-9. [PMID: 33945640]
47. 進行がん患者と家族介護者による医師とのコミュニケーション・ケア調整の評価についての縦断的研究
Malhotra C, Chaudhry I, Ozdemir S, Teo I, Kanesvaran R, Group CS. Experiences with health care practitioners among advanced cancer patients and their family caregivers: A longitudinal dyadic study. Cancer. 2021;127(16):3002-9. [PMID: 33878215]
48. がん医療提供者への喫煙と依存のアセスメント・治療に関する教育
Ostroff JS, Bolutayo Gaffney KL, O'Brien M, deLeon-Sanchez ST, Whitlock CW, Kotsen CS, et al. Training oncology care providers in the assessment and treatment of tobacco use and dependence. Cancer. 2021;127(16):3010-8. [PMID: 33914922]

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