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Japanese Society for Palliative Medicine
News Letter No.88
日本緩和医療学会ニューズレター
Aug 2020  88
Journal Watch
緩和ケアに関する論文レビュー
名古屋大学大学院医学系研究科 総合保健学専攻高度実践看護開発学講座
佐藤 一樹

対象雑誌:N Engl J Med, Lancet, Lancet Oncol, JAMA, JAMA Intern Med, JAMA Oncol, BMJ, Ann Intern Med, J Clin Oncol, Ann Oncol, Eur J Cancer, Br J Cancer, Cancer

対象期間:2020年3月〜2020年5月刊行分

いわゆる“トップジャーナル”に掲載された緩和ケアに関する最新論文を広く紹介します。


【N Engl J Med. 2020;382(10-22)】
1.がんに関連した静脈血栓塞栓症VTEに対するアピキサバンとダルテパリンの無作為化比較試験
Agnelli G, Becattini C, Meyer G, Munoz A, Huisman MV, Connors JM, et al. Apixaban for the Treatment of Venous Thromboembolism Associated with Cancer. N Engl J Med. 2020;382(17):1599-607. [PMID: 32223112]

【Lancet. 2020;395(10226-10238)】
2.緩和ケアとCovid-19パンデミック(Editorial)
The L. Palliative care and the COVID-19 pandemic. Lancet. 2020;395(10231):1168. [PMID: 32278369]
3.Covid-19パンデミックでの緩和ケアの役割(Comment)
Radbruch L, Knaul FM, de Lima L, de Joncheere C, Bhadelia A. The key role of palliative care in response to the COVID-19 tsunami of suffering. Lancet. 2020;395(10235):1467-9. [PMID: 32333842]

【Lancet Oncol.2020;21(3-5)】
4.若年成人がんの長期サバイバーの死亡と健康障害リスク
Suh E, Stratton KL, Leisenring WM, Nathan PC, Ford JS, Freyer DR, et al. Late mortality and chronic health conditions in long-term survivors of early-adolescent and young adult cancers: a retrospective cohort analysis from the Childhood Cancer Survivor Study. Lancet Oncol. 2020;21(3):421-35. [PMID: 32066543]
5.小児がんの女性長期サバイバーの急性卵巣機能不全のリスク予測モデル
Clark RA, Mostoufi-Moab S, Yasui Y, Vu NK, Sklar CA, Motan T, et al. Predicting acute ovarian failure in female survivors of childhood cancer: a cohort study in the Childhood Cancer Survivor Study (CCSS) and the St Jude Lifetime Cohort (SJLIFE). Lancet Oncol. 2020;21(3):436-45. [PMID: 32066539]
6.肺がん特異的QOL評価尺度EORTC QLQ-LC29の計量心理学的特性
Koller M, Shamieh O, Hjermstad MJ, Hornslien K, Young T, Chalk T, et al. Psychometric properties of the updated EORTC module for assessing quality of life in patients with lung cancer (QLQ-LC29): an international, observational field study. Lancet Oncol. 2020;21(5):723-32. [PMID: 32213338]

【JAMA. 2020;323(9-20)】
7.終末期患者のACP文書とICU入室の関係
Lee RY, Brumback LC, Sathitratanacheewin S, Lober WB, Modes ME, Lynch YT, et al. Association of Physician Orders for Life-Sustaining Treatment With ICU Admission Among Patients Hospitalized Near the End of Life. JAMA. 2020. [PMID: 32062674]

【JAMA Intern Med. 2020;6(3-5)】
8.電子カルテの初期値変更による救急外来でのオピオイド処方の変化
Montoy JCC, Coralic Z, Herring AA, Clattenburg EJ, Raven MC. Association of Default Electronic Medical Record Settings With Health Care Professional Patterns of Opioid Prescribing in Emergency Departments: A Randomized Quality Improvement Study. JAMA Intern Med. 2020. [PMID: 31961377]
9.米国での2015〜2018年の高齢者での医療用大麻使用の傾向
Han BH, Palamar JJ. Trends in Cannabis Use Among Older Adults in the United States, 2015-2018. JAMA Intern Med. 2020. [PMID: 32091531]
10.QT延長作用のある薬剤処方と突然死の関連:検死データの分析
Simpson TF, Salazar JW, Vittinghoff E, Probert J, Iwahashi A, Olgin JE, et al. Association of QT-Prolonging Medications With Risk of Autopsy-Defined Causes of Sudden Death. JAMA Intern Med. 2020. [PMID: 32119028]
11.米国のオバマケアとオピオイド関連受診率の関係
Wen H, Soni A, Hollingsworth A, Freedman S, Benitez J, Simon K, et al. Association Between Medicaid Expansion and Rates of Opioid-Related Hospital Use. JAMA Intern Med. 2020. [PMID: 32202609]

【JAMA Oncol. 2020;180(3-5)】
なし

【BMJ. 2020;368(8236-8247)】
12.オピオイド鎮痛薬の処方中止と処方期間、過剰摂取、自殺の関連
Oliva EM, Bowe T, Manhapra A, Kertesz S, Hah JM, Henderson P, et al. Associations between stopping prescriptions for opioids, length of opioid treatment, and overdose or suicide deaths in US veterans: observational evaluation. BMJ. 2020;368:m283. [PMID: 32131996]
13.オピオイド使用障害に対する治療効果の疫学調査
Pearce LA, Min JE, Piske M, Zhou H, Homayra F, Slaunwhite A, et al. Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study. BMJ. 2020;368:m772. [PMID: 32234712]
14.医療用大麻のNICEガイドラインの紹介(Practice)
Chang-Douglass S, Mulvihill C, Pilling S, Guideline C. Cannabis-based medicinal products: summary of NICE guidance. BMJ. 2020;369:m1108. [PMID: 32317246]
15.Covid-19パンデミック下での家族による終末期患者への薬物投与(Editorial)
Bowers B, Pollock K, Barclay S. Administration of end-of-life drugs by family caregivers during covid-19 pandemic. BMJ. 2020;369:m1615. [PMID: 32332027]
16.神経障害性疼痛に対するプレガバリンとガバペンチンの概説(Practice)
Mathieson S, Lin CC, Underwood M, Eldabe S. Pregabalin and gabapentin for pain. BMJ. 2020;369:m1315. [PMID: 32345589]

【Ann Intern Med. 2020;173(5-10)】
17.肥満とホスピス利用の関連
Harris JA, Byhoff E, Perumalswami CR, Langa KM, Wright AA, Griggs JJ. The Relationship of Obesity to Hospice Use and Expenditures: A Cohort Study. Ann Intern Med. 2017;166(6):381-9. [PMID: 28166546]

【J Clin Oncol. 2020;18038(7-15)】
18.乳がん治療の就業への影響
Dumas A, Vaz Luis I, Bovagnet T, El Mouhebb M, Di Meglio A, Pinto S, et al. Impact of Breast Cancer Treatment on Employment: Results of a Multicenter Prospective Cohort Study (CANTO). J Clin Oncol. 2020;38(7):734-43. [PMID: 31834818]
19.がん患者に対する緩和ケアの提供モデルの総説
Temel JS, Jacobsen PB. Palliative Care in Oncology: Continuing to Build the Evidence Base and Disseminate Effective Care Models. J Clin Oncol. 2020;38(9):849-51. [PMID: 32023160]
20.進行がん患者の緩和ケアでの患者と医師のコミュニケーションの総説
Back AL. Patient-Clinician Communication Issues in Palliative Care for Patients With Advanced Cancer. J Clin Oncol. 2020;38(9):866-76.[PMID: 32023153]
21.がん緩和ケアでの予後認識の総説
Butow PN, Clayton JM, Epstein RM. Prognostic Awareness in Adult Oncology and Palliative Care. J Clin Oncol. 2020;38(9):877-84. [PMID: 32023158]
22.進行がん患者に対する心理介入の総説
Rodin G, An E, Shnall J, Malfitano C. Psychological Interventions for Patients With Advanced Disease: Implications for Oncology and Palliative Care. J Clin Oncol. 2020;38(9):885-904. [PMID: 32023159]
23.進行がんでの症状緩和の総説:痛み、息切れ、悪心・嘔吐、倦怠感
Henson LA, Maddocks M, Evans C, Davidson M, Hicks S, Higginson IJ. Palliative Care and the Management of Common Distressing Symptoms in Advanced Cancer: Pain, Breathlessness, Nausea and Vomiting, and Fatigue. J Clin Oncol. 2020;38(9):905-14. [PMID: 32023162]
24.進行がん患者への緩和ケアでのコーピングの役割の総説
Greer JA, Applebaum AJ, Jacobsen JC, Temel JS, Jackson VA. Understanding and Addressing the Role of Coping in Palliative Care for Patients With Advanced Cancer. J Clin Oncol. 2020;38(9):915-25. [PMID: 32023161]
25.緩和ケアでの家族ケアの総説
Alam S, Hannon B, Zimmermann C. Palliative Care for Family Caregivers. J Clin Oncol. 2020;38(9):926-36. [PMID: 32023152]
26.脳転移に対する全脳照射でのメマチニンと海馬照射回避の無作為化比較試験
Brown PD, Gondi V, Pugh S, Tome WA, Wefel JS, Armstrong TS, et al. Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001. J Clin Oncol. 2020;38(10):1019-29. [PMID: 32058845]

【Ann Oncol. 2020;31(3-5)】
なし

【Eur J Cancer. 2020;127-131】
27.小児期の白血病罹患と胎児成長の関連
Karalexi MA, Dessypris N, Ma X, Spector LG, Marcotte E, Clavel J, et al. Age-, sex- and disease subtype-related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis. Eur J Cancer. 2020;130:1-11. [PMID: 32163883]
28.小児がん患者に対する穿刺の痛みの軽減と予防のための臨床ガイドライン
Loeffen EAH, Mulder RL, Font-Gonzalez A, Leroy P, Dick BD, Taddio A, et al. Reducing pain and distress related to needle procedures in children with cancer: A clinical practice guideline. Eur J Cancer. 2020;131:53-67. [PMID: 32302949]

【Br J Cancer. 2020;122(5-11)】
29.AYA世代若年がんサバイバーの出産時アウトカム
Kao WH, Kuo CF, Chiou MJ, Liu YC, Wang CC, Hong JH, et al. Adverse birth outcomes in adolescent and young adult female cancer survivors: a nationwide population-based study. Br J Cancer. 2020;122(6):918-24. [PMID: 31929517]
30.生活習慣と発がんリスク
Zhang YB, Pan XF, Chen J, Cao A, Zhang YG, Xia L, et al. Combined lifestyle factors, incident cancer, and cancer mortality: a systematic review and meta-analysis of prospective cohort studies. Br J Cancer. 2020;122(7):1085-93. [PMID: 32037402]

【Cancer. 2020;126(5-10)】
31.がん患者に対する患者ナビゲーターの心理社会的支援の無作為化比較試験
Ramirez AG, Choi BY, Munoz E, Perez A, Gallion KJ, Moreno PI, et al. Assessing the effect of patient navigator assistance for psychosocial support services on health-related quality of life in a randomized clinical trial in Latino breast, prostate, and colorectal cancer survivors. Cancer. 2020;126(5):1112-23. [PMID: 31743436]
32.限局性乳がん患者の配偶者の賃金の損失
Humphries B, Lauzier S, Drolet M, Coyle D, Masse B, Provencher L, et al. Wage losses among spouses of women with nonmetastatic breast cancer. Cancer. 2020;126(5):1124-34. [PMID: 31821547]
33.血液がんの根治可能性に関する血液腫瘍医の認識の不一致
Loh KP, Xu H, Back A, Duberstein PR, Gupta Mohile S, Epstein R, et al. Patient-hematologist discordance in perceived chance of cure in hematologic malignancies: A multicenter study. Cancer. 2020;126(6):1306-14. [PMID: 31809566]
34.施設入居高齢がん患者に負担の大きい終末期の療養場所の移動
Lage DE, DuMontier C, Lee Y, Nipp RD, Mitchell SL, Temel JS, et al. Potentially burdensome end-of-life transitions among nursing home residents with poor-prognosis cancer. Cancer. 2020;126(6):1322-9. [PMID: 31860129]
35.がん患者でのてんかん発作
Gonzalez Castro LN, Milligan TA. Seizures in patients with cancer. Cancer. 2020;126(7):1379-89. [PMID: 31967671]
36.化学療法中の頭頚部がん患者に対するガバペンチンとメサドンの単施設無作為化比較試験
Hermann GM, Iovoli AJ, Platek AJ, Wang C, Miller A, Attwood K, et al. A single-institution, randomized, pilot study evaluating the efficacy of gabapentin and methadone for patients undergoing chemoradiation for head and neck squamous cell cancer. Cancer. 2020;126(7):1480-91. [PMID: 31869451]
37.甲状腺がん患者の再発・死亡リスクの認識と実際のリスクの乖離
Chen DW, Reyes-Gastelum D, Wallner LP, Papaleontiou M, Hamilton AS, Ward KC, et al. Disparities in risk perception of thyroid cancer recurrence and death. Cancer. 2020;126(7):1512-21. [PMID: 31869452]
38.乳がん診断後の心血管リスクに対する処方のアドヒアランスと心血管イベントとの関連
Hershman DL, Accordino MK, Shen S, Buono D, Crew KD, Kalinsky K, et al. Association between nonadherence to cardiovascular risk factor medications after breast cancer diagnosis and incidence of cardiac events. Cancer. 2020;126(7):1541-9. [PMID: 31913500]
39.免疫チェックポイント阻害薬に関するQOL評価尺度FACT-ICMの開発
Hansen AR, Ala-Leppilampi K, McKillop C, Siu LL, Bedard PL, Abdul Razak AR, et al. Development of the Functional Assessment of Cancer Therapy-Immune Checkpoint Modulator (FACT-ICM): A toxicity subscale to measure quality of life in patients with cancer who are treated with ICMs. Cancer. 2020;126(7):1550-8. [PMID: 31914209]
40.乳がん患者の死因:米国の全国調査
Afifi AM, Saad AM, Al-Husseini MJ, Elmehrath AO, Northfelt DW, Sonbol MB. Causes of death after breast cancer diagnosis: A US population-based analysis. Cancer. 2020;126(7):1559-67. [PMID: 31840240]
41.若年がん患者の抑うつのPROMIS Depression Short Formによるスクリーニングの評価
Recklitis CJ, Blackmon JE, Chang G. Screening young adult cancer survivors with the PROMIS Depression Short Form (PROMIS-D-SF): Comparison with a structured clinical diagnostic interview. Cancer. 2020;126(7):1568-75. [PMID: 31913510]
42.小児悪性軟部腫瘍の成人サバイバーでの認知的・心理社会的アウトカム
Tonning Olsson I, Brinkman TM, Wang M, Ehrhardt MJ, Banerjee P, Mulrooney DA, et al. Neurocognitive and psychosocial outcomes in adult survivors of childhood soft-tissue sarcoma: A report from the St. Jude Lifetime Cohort. Cancer. 2020;126(7):1576-84. [PMID: 31913509]
43.がん臨床試験の評価項目に対する患者の親しみ・理解・希望
von Itzstein MS, Railey E, Smith ML, White CB, Sledge GW, Jr., Howell JR, et al. Patient familiarity with, understanding of, and preferences for clinical trial endpoints and terminology. Cancer. 2020;126(8):1605-13. [PMID: 31967687]
44.高齢固形がん患者での栄養評価と化学療法の有害事象との関連
Dotan E, Tew WP, Mohile SG, Ma H, Kim H, Sun CL, et al. Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors. Cancer. 2020;126(8):1708-16. [PMID: 31977084]
45.がん化学療法の有効性と有害事象の臨床試験と実臨床での比較
Phillips CM, Parmar A, Guo H, Schwartz D, Isaranuwatchai W, Beca J, et al. Assessing the efficacy-effectiveness gap for cancer therapies: A comparison of overall survival and toxicity between clinical trial and population-based, real-world data for contemporary parenteral cancer therapeutics. Cancer. 2020;126(8):1717-26. [PMID: 31913522]
46.がん診断前後での糖尿病治療の変化
Pinheiro LC, Soroka O, Kern LM, Leonard JP, Safford MM. Diabetes care management patterns before and after a cancer diagnosis: A SEER-Medicare matched cohort study. Cancer. 2020;126(8):1727-35. [PMID: 31999848]
47.直接経口抗凝固薬によるがん関連血栓症予防の費用対効果
Li A, Carlson JJ, Kuderer NM, Schaefer JK, Li S, Garcia DA, et al. Cost-effectiveness analysis of low-dose direct oral anticoagulant (DOAC) for the prevention of cancer-associated thrombosis in the United States. Cancer. 2020;126(8):1736-48. [PMID: 31999844]
48.造血幹細胞移植を受ける患者の家族に対する心理介入の無作為化比較試験
El-Jawahri A, Jacobs JM, Nelson AM, Traeger L, Greer JA, Nicholson S, et al. Multimodal psychosocial intervention for family caregivers of patients undergoing hematopoietic stem cell transplantation: A randomized clinical trial. Cancer. 2020;126(8):1758-65. [PMID: 31899552]
49.閉経後女性大腸がん患者での診断前の社会的状況と予後との関連
Kroenke CH, Paskett ED, Cene CW, Caan BJ, Luo J, Shadyab AH, et al. Prediagnosis social support, social integration, living status, and colorectal cancer mortality in postmenopausal women from the women's health initiative. Cancer. 2020;126(8):1766-75. [PMID: 31972054]
50.小児・若年がん患者での聴力低下に関する質的研究
Khan A, Mubdi N, Budnick A, Feldman DR, Williams SW, Patel S, et al. The experience of hearing loss in adult survivors of childhood and young adult cancer: A qualitative study. Cancer. 2020;126(8):1776-83. [PMID: 31899553]
51.がん患者の家族の再発恐怖とがん検診受診行動との関連
Takeuchi E, Kim Y, Shaffer KM, Cannady RS, Carver CS. Fear of cancer recurrence promotes cancer screening behaviors among family caregivers of cancer survivors. Cancer. 2020;126(8):1784-92. [PMID: 31913499]
52.黒人がん患者の運動習慣とQOLの関係
Beebe-Dimmer JL, Ruterbusch JJ, Harper FWK, Baird TM, Finlay DG, Rundle AG, et al. Physical activity and quality of life in African American cancer survivors: The Detroit Research on Cancer Survivors study. Cancer. 2020;126(9):1987-94. [PMID: 32090322]
53.骨髄移植後の高齢血液がん患者の痛み
Farrukh N, Hageman L, Chen Y, Wu J, Ness E, Kung M, et al. Pain in older survivors of hematologic malignancies after blood or marrow transplantation: A BMTSS report. Cancer. 2020;126(9):2003-12. [PMID: 32022263]
54.米国のがん拠点病院での緩和ケアの現況
Hui D, De La Rosa A, Chen J, Dibaj S, Delgado Guay M, Heung Y, et al. State of palliative care services at US cancer centers: An updated national survey. Cancer. 2020;126(9):2013-23. [PMID: 32049358]
55.低中所得国での医療リソース別の緩和ケアガイドラインの医療者教育:ジャマイカでの教訓
Stoltenberg M, Spence D, Daubman BR, Greaves N, Edwards R, Bromfield B, et al. The central role of provider training in implementing resource-stratified guidelines for palliative care in low-income and middle-income countries: Lessons from the Jamaica Cancer Care and Research Institute in the Caribbean and Universidad Catolica in Latin America. Cancer. 2020;126 Suppl 10:2448-57. [PMID: 32348569]
56.骨髄移植患者の認知機能障害の自覚と客観評価の関係
Murdaugh DL, Bosworth A, Patel SK, Sharafeldin N, Chen Y, Francisco L, et al. Self-endorsed cognitive problems versus objectively assessed cognitive impairment in blood or bone marrow transplantation recipients: A longitudinal study. Cancer. 2020;126(10):2174-82. [PMID: 32097508]
57.免疫療法を受ける非小細胞肺がん患者のPSと終末期ケアの関連
Petrillo LA, El-Jawahri A, Nipp RD, Lichtenstein MRL, Durbin SM, Reynolds KL, et al. Performance status and end-of-life care among adults with non-small cell lung cancer receiving immune checkpoint inhibitors. Cancer. 2020;126(10):2288-95. [PMID: 32142165]
58.乳がん診断後10年でのQOLの変化:Pink SWAN研究
Avis NE, Levine B, Goyal N, Crawford SL, Hess R, Colvin A, et al. Health-related quality of life among breast cancer survivors and noncancer controls over 10 years: Pink SWAN. Cancer. 2020;126(10):2296-304. [PMID: 32105350]

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