line
Japanese Society for Palliative Medicine
News Letter No.87
日本緩和医療学会ニューズレター
May 2020  87
Journal Watch
緩和ケアに関する論文レビュー
名古屋大学大学院医学系研究科 総合保健学専攻高度実践看護開発学講座
佐藤 一樹

対象雑誌:N Engl J Med, Lancet, Lancet Oncol, JAMA, JAMA Intern Med, JAMA Oncol, BMJ, Ann Intern Med, J Clin Oncol, Ann Oncol, Eur J Cancer, Br J Cancer, Cancer

対象期間:2019年12月〜2020年2月刊行分

いわゆる“トップジャーナル”に掲載された緩和ケアに関する最新論文を広く紹介します。


【N Engl J Med. 2019;381(23-26), 2020;382(1-9)】
なし

【Lancet. 2019;394(10214-10216), 2020;395(10217-10225)】
なし

【Lancet Oncol. 2019;20(12), 2020;21(1-2)】
1.患者報告アウトカムと予後との関連のレビュー
Mierzynska J, Piccinin C, Pe M, Martinelli F, Gotay C, Coens C, et al. Prognostic value of patient-reported outcomes from international randomised clinical trials on cancer: a systematic review. Lancet Oncol. 2019;20(12):e685-e98. [PMID: 31797795]
2.診断時のがん進行度と症状の関連
Koo MM, Swann R, McPhail S, Abel GA, Elliss-Brookes L, Rubin GP, et al. Presenting symptoms of cancer and stage at diagnosis: evidence from a cross-sectional, population-based study. Lancet Oncol. 2020;21(1):73-9. [PMID: 31704137]
3.症状とQOLの自己管理支援アプリOncokompasの無作為化比較試験
van der Hout A, van Uden-Kraan CF, Holtmaat K, Jansen F, Lissenberg-Witte BI, Nieuwenhuijzen GAP, et al. Role of eHealth application Oncokompas in supporting self-management of symptoms and health-related quality of life in cancer survivors: a randomised, controlled trial. Lancet Oncol. 2020;21(1):80-94. [PMID: 31838009]
4.オランザピン5mg上乗せによる化学療法誘発悪心・嘔吐の予防効果の無作為化比較試験(J-FORCE試験)
Hashimoto H, Abe M, Tokuyama O, Mizutani H, Uchitomi Y, Yamaguchi T, et al. Olanzapine 5 mg plus standard antiemetic therapy for the prevention of chemotherapy-induced nausea and vomiting (J-FORCE): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2020;21(2):242-9. [PMID: 31838011]

【JAMA. 2019;322(21-24), 2020;323(1-8)】
5.脊髄圧迫治療での単回照射と5分割照射の無作為化比較試験
Hoskin PJ, Hopkins K, Misra V, Holt T, McMenemin R, Dubois D, et al. Effect of Single-Fraction vs Multifraction Radiotherapy on Ambulatory Status Among Patients With Spinal Canal Compression From Metastatic Cancer: The SCORAD Randomized Clinical Trial. JAMA. 2019;322(21):2084-94. [PMID: 31794625]
6.米国の2000〜2017年のオピオイド過剰摂取の傾向(短報)
Olfson M, Rossen LM, Wall MM, Houry D, Blanco C. Trends in Intentional and Unintentional Opioid Overdose Deaths in the United States, 2000-2017. JAMA. 2019;322(23):2340-2. [PMID: 31846008]
7.米国の2009〜2018年のブプレノルフィン処方の傾向(短報)
Olfson M, Zhang VS, Schoenbaum M, King M. Trends in Buprenorphine Treatment in the United States, 2009-2018. JAMA. 2020;323(3):276-7. [PMID: 31961408]
8.米国の学生での電子たばこでのマリファナ吸入の実態(短報)
Dai H. Self-reported Marijuana Use in Electronic Cigarettes Among US Youth, 2017 to 2018. JAMA. 2019;325(5):473-4. [PMID: 31848567]
9.米国の学生での加熱式たばこを用いたマリファナ吸入の実態(短報)
Miech RA, Patrick ME, O'Malley PM, Johnston LD, Bachman JG. Trends in Reported Marijuana Vaping Among US Adolescents, 2017-2019. JAMA. 2019;323(5):475-6. [PMID: 31848566]
10.米国のホスピスでの処方薬の譲渡の実態(短報)
Cagle JG, McPherson ML, Frey JJ, Sacco P, Ware OD, Wiegand DL, et al. Estimates of Medication Diversion in Hospice. JAMA. 2020;323(6):566-8. [PMID: 32044935]
11.米国の2002〜2018年のヘロイン使用の実態(短報)
Han B, Volkow ND, Compton WM, McCance-Katz EF. Reported Heroin Use, Use Disorder, and Injection Among Adults in the United States, 2002-2018. JAMA. 2020;323(6):568-71. [PMID: 32044936]

【JAMA Intern Med. 2019;179(12), 2020;180(1-2)】
12.7か国のナーシングホームでの早期緩和ケアのクラスター無作為化比較試験(PACE試験)
Van den Block L, Honinx E, Pivodic L, Miranda R, Onwuteaka-Philipsen BD, van Hout H, et al. Evaluation of a Palliative Care Program for Nursing Homes in 7 Countries: The PACE Cluster-Randomized Clinical Trial. JAMA Intern Med. 2019;180(2):1-10. [PMID: 31710345]

【JAMA Oncol. 2019;5(12), 2020;6(1-2)】
13.進行肺がん患者での早期緩和ケアと予後や死亡場所との関連
Sullivan DR, Chan B, Lapidus JA, Ganzini L, Hansen L, Carney PA, et al. Association of Early Palliative Care Use With Survival and Place of Death Among Patients With Advanced Lung Cancer Receiving Care in the Veterans Health Administration. JAMA Oncol. 2019;5(12):1702-9. [PMID: 31536133]
14.世界の1990〜2017年のがんの罹患、予後、生涯調整生存年数
Global Burden of Disease Cancer C, Fitzmaurice C, Abate D, Abbasi N, Abbastabar H, Abd-Allah F, et al. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2019;5(12):1749-68. [PMID: 31560378]
15.がん終末期ケアの地域単位の質指標のレビュー
Henson LA, Edmonds P, Johnston A, Johnson HE, Ng Yin Ling C, Sklavounos A, et al. Population-Based Quality Indicators for End-of-Life Cancer Care: A Systematic Review. JAMA Oncol. 2019;6(1):142-50. [PMID: 31647512]
16.高齢がん患者とのコミュニケーションに対する高齢者評価のクラスター無作為化比較試験
Mohile SG, Epstein RM, Hurria A, Heckler CE, Canin B, Culakova E, et al. Communication With Older Patients With Cancer Using Geriatric Assessment: A Cluster-Randomized Clinical Trial From the National Cancer Institute Community Oncology Research Program. JAMA Oncol. 2019;6(2):1-9. [PMID: 31697365]
17.がん疼痛に対する鍼と指圧の効果のメタアナリシス
He Y, Guo X, May BH, Zhang AL, Liu Y, Lu C, et al. Clinical Evidence for Association of Acupuncture and Acupressure With Improved Cancer Pain: A Systematic Review and Meta-Analysis. JAMA Oncol. 2019;6(2):271-8. [PMID: 31855257]

【BMJ 2019;366(8225-8227), 2020;367(8228-8235)】
18.米国の2003〜2017年のオピオイド鎮痛薬処方の医師単位での検討
Kiang MV, Humphreys K, Cullen MR, Basu S. Opioid prescribing patterns among medical providers in the United States, 2003-17: retrospective, observational study. BMJ. 2020;368:l6968. [PMID: 31996352]

【Ann Intern Med. 2019;171(11-12), 2020;173(1-4)】
19.終末期患者の意向と価値観を聴取する介入3 Wishes ProjectのICUでの混合研究
Vanstone M, Neville TH, Clarke FJ, Swinton M, Sadik M, Takaoka A, et al. Compassionate End-of-Life Care: Mixed-Methods Multisite Evaluation of the 3 Wishes Project. Ann Intern Med. 2019;172(1):1-11. [PMID: 31711111]

【J Clin Oncol. 2019;37(34-36), 2020;38(1-6)】
20.小児がん患者の母親ときょうだいの長期的な精神健康
van Warmerdam J, Sutradhar R, Kurdyak P, Lau C, Pole JD, Nathan PC, et al. Long-Term Mental Health Outcomes in Mothers and Siblings of Children With Cancer: A Population-Based, Matched Cohort Study. J Clin Oncol. 2020;38(1):51-62. [PMID: 31714869]
21.小児がん死別後の両親の遷延性悲嘆の要因
Pohlkamp L, Kreicbergs U, Sveen J. Factors During a Child's Illness Are Associated With Levels of Prolonged Grief Symptoms in Bereaved Mothers and Fathers. J Clin Oncol. 2020;38(2):137-44. [PMID: 31725342]
22.がん患者での静脈血栓塞栓症のASCO臨床診療ガイドライン
Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, et al. Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol. 2020;38(5):496-520. [PMID: 31381464]
23.米国のがん患者の経済的問題のレビュー
Yabroff KR, Bradley C, Shih YT. Understanding Financial Hardship Among Cancer Survivors in the United States: Strategies for Prevention and Mitigation. J Clin Oncol. 2020;38(4):292-301. [PMID: 31804869]
24.がんの雇用への影響のレビュー
Blinder VS, Gany FM. Impact of Cancer on Employment. J Clin Oncol. 2020;38(4):302-9. [PMID: 31804857]
25.がん治療の費用の推移のレビュー
Laviana AA, Luckenbaugh AN, Resnick MJ. Trends in the Cost of Cancer Care: Beyond Drugs. J Clin Oncol. 2020;38(4):316-22. [PMID: 31804864]
26.がん患者の支出と転帰の関連のレビュー
Li M, Lakdawalla DN, Goldman DP. Association Between Spending and Outcomes for Patients With Cancer. J Clin Oncol. 2020;38(4):323-31. [PMID: 31804868]

【Ann Oncol. 2019;30(12), 2020;31(1-2)】
27.がん関連の認知機能障害のレビュー
Lange M, Joly F, Vardy J, Ahles T, Dubois M, Tron L, et al. Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors. Ann Oncol. 2019;30(12):1925-40. [PMID: 31617564]
28.放射線化学療法中の肺がん患者に対する支持療法の推奨
De Ruysscher D, Faivre-Finn C, Nackaerts K, Jordan K, Arends J, Douillard JY, et al. Recommendation for supportive care in patients receiving concurrent chemotherapy and radiotherapy for lung cancer. Ann Oncol. 2020;31(1):41-9. [PMID: 31912794]
29.肺がん患者の経済的問題とQOLへの影響
Hazell SZ, Fu W, Hu C, Voong KR, Lee B, Peterson V, et al. Financial toxicity in lung cancer: an assessment of magnitude, perception, and impact on quality of life. Ann Oncol. 2020;31(1):96-102. [PMID: 31912803]
30.がん治療中の進行がん患者の重度の倦怠感に対する認知行動療法と段階的運動療法無作為化比較試験
Poort H, Peters M, van der Graaf WTA, Nieuwkerk PT, van de Wouw AJ, Nijhuis-van der Sanden MWG, et al. Cognitive behavioral therapy or graded exercise therapy compared with usual care for severe fatigue in patients with advanced cancer during treatment: a randomized controlled trial. Ann Oncol. 2020;31(1):115-22. [PMID: 31912784]
31.進行がん患者に対する電子的症状モニタリング介入の年齢による効果の違い
Nipp RD, Horick NK, Deal AM, Rogak LJ, Fuh C, Greer JA, et al. Differential effects of an electronic symptom monitoring intervention based on the age of patients with advanced cancer. Ann Oncol. 2020;31(1):123-30. [PMID: 31912785]
32.化学療法誘発性末梢神経障害予防の冷却グルーブの無作為化比較試験
Beijers AJM, Bonhof CS, Mols F, Ophorst J, de Vos-Geelen J, Jacobs EMG, et al. Multicenter randomized controlled trial to evaluate the efficacy and tolerability of frozen gloves for the prevention of chemotherapy-induced peripheral neuropathy. Ann Oncol. 2020;31(1):131-6. [PMID: 31912787]

【Eur J Cancer. 2019;123, 2020;124-126】
33.早期緩和ケア介入の終末期のQOLや医療利用への影響:無作為化比較試験
Vanbutsele G, Van Belle S, Surmont V, De Laat M, Colman R, Eecloo K, et al. The effect of early and systematic integration of palliative care in oncology on quality of life and health care use near the end of life: A randomised controlled trial. Eur J Cancer. 2020;124:186-93. [PMID: 31812934]
34.進行乳がん患者のQOL評価EORTC QLQ-C30の参照値(標準値)
Mierzynska J, Taye M, Pe M, Coens C, Martinelli F, Pogoda K, et al. Reference values for the EORTC QLQ-C30 in early and metastatic breast cancer. Eur J Cancer. 2020;125:69-82. [PMID: 31838407]
35.がん患者の自殺のメタアナリシス
Ravaioli A, Crocetti E, Mancini S, Baldacchini F, Giuliani O, Vattiato R, et al. Suicide death among cancer patients: new data from northern Italy, systematic review of the last 22 years and meta-analysis. Eur J Cancer. 2020;125:104-13. [PMID: 31862504]

【Br J Cancer. 2019;121(12), 2020;122(1-4)】
36.肺がん患者対象の症状の啓発キャンペーンの効果
McCutchan G, Smits S, Ironmonger L, Slyne C, Boughey A, Moffat J, et al. Evaluation of a national lung cancer symptom awareness campaign in Wales. Br J Cancer. 2020;122(4):491-7. [PMID: 31839675]

【Cancer. 2019;125(23-24), 2020;126(1-4)】
37.がん診断後9年での喫煙者と禁煙者での再発恐怖の比較
Westmaas JL, Thewes B, Seguin Leclair C, Lebel S. Smoking versus quitting and fear of cancer recurrence 9 years after diagnosis in the American Cancer Society's Longitudinal Study of Cancer Survivors-I (SCS-I). Cancer. 2019;125(23):4260-8. [PMID: 31390060]
38.脊椎転移の手術と放射線療法の患者満足
Versteeg AL, Sahgal A, Kawahara N, Rhines LD, Sciubba DM, Weber MH, et al. Patient satisfaction with treatment outcomes after surgery and/or radiotherapy for spinal metastases. Cancer. 2019;125(23):4269-77. [PMID:31490548]
39.進行消化器がん患者の悪液質に対するアナモレリンの介入試験
Hamauchi S, Furuse J, Takano T, Munemoto Y, Furuya K, Baba H, et al. A multicenter, open-label, single-arm study of anamorelin (ONO-7643) in advanced gastrointestinal cancer patients with cancer cachexia. Cancer. 2019;125(23):4294-302. [PMID: 31415709]
40.米国の2010〜2017年のがんサバイバーの慢性痛の有症率
Sanford NN, Sher DJ, Butler SS, Xu X, Ahn C, Aizer AA, et al. Prevalence of chronic pain among cancer survivors in the United States, 2010-2017. Cancer. 2019;125(23):4310-8. [PMID: 31436323]
41.緩和ケア外来紹介がん患者でのオピオイド鎮痛薬と鎮静薬の併用
Haider A, Azhar A, Nguyen K, Dev R, Naqvi SMA, Naqvi SMA, et al. Concurrent use of opioids with benzodiazepines or nonbenzodiazepine sedatives among patients with cancer referred to an outpatient palliative care clinic. Cancer. 2019;125(24):4525-31. [PMID: 31460669]
42.血液がん患者での治療目標の話し合いと終末期ケアとの関連
Odejide OO, Uno H, Murillo A, Tulsky JA, Abel GA. Goals of care discussions for patients with blood cancers: Association of person, place, and time with end-of-life care utilization. Cancer. 2020;126(3):515-22. [PMID: 31593321]
43.手術を受ける高齢がん患者の精神科ケア利用の関連要因
Trevino KM, Nelson CJ, Saracino RM, Korc-Grodzicki B, Sarraf S, Shahrokni A. Is screening for psychosocial risk factors associated with mental health care in older adults with cancer undergoing surgery? Cancer. 2020;126(3):602-10. [PMID: 31626346]
44.小児がんの成人サバイバーでのがん関連外来受診の関連要因
Ford JS, Tonorezos ES, Mertens AC, Hudson MM, Casillas J, Foster BM, et al. Barriers and facilitators of risk-based health care for adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer. 2020;126(3):619-27. [PMID: 31626337]
45.精巣がん患者の白金製剤曝露と予後の関連
Groot HJ, van Leeuwen FE, Lubberts S, Horenblas S, de Wit R, Witjes JA, et al. Platinum exposure and cause-specific mortality among patients with testicular cancer. Cancer. 2020;126(3):628-39. [PMID: 31730712]
46.小児白血病の成人サバイバーでの運動と認知機能の関連
Phillips NS, Howell CR, Lanctot JQ, Partin RE, Pui CH, Hudson MM, et al. Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort. Cancer. 2020;126(3):640-8. [PMID: 31631333]
47.頭頚部がんサバイバーの呼吸器関連の転帰
Kawakita D, Abdelaziz S, Chen Y, Rowe K, Snyder J, Fraser A, et al. Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study. Cancer. 2020;126(4):879-85. [PMID: 31721181]
48.高齢乳がん患者のがん治療後の新規徐放オピオイド鎮痛薬の継続使用
Roberts AW, Fergestrom N, Neuner JM, Winn AN. New-onset persistent opioid use following breast cancer treatment in older adult women. Cancer. 2020;126(4):814-22. [PMID: 31846054]
49.進行がん患者の予後認識と奇跡に対する信仰心の関連
George LS, Balboni TA, Maciejewski PK, Epstein AS, Prigerson HG. "My doctor says the cancer is worse, but I believe in miracles"-When religious belief in miracles diminishes the impact of news of cancer progression on change in prognostic understanding. Cancer. 2020;126(4):832-9. [PMID: 31658374]
50.貧困であるAYA世代若年がん患者での終末期ケア
Roeland EJ, Lindley LC, Gilbertson-White S, Saeidzadeh S, Currie ER, Friedman S, et al. End-of-life care among adolescent and young adult patients with cancer living in poverty. Cancer. 2020;126(4):886-93. [PMID: 31724747]

Close