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Japanese Society for Palliative Medicine
News Letter No.83
日本緩和医療学会ニューズレター
May 2019  83
Journal Watch
緩和ケアに関する論文レビュー
名古屋大学大学院医学系研究科 看護学専攻基礎・臨床看護学講座
佐藤 一樹
対象雑誌:N Engl J Med, Lancet, Lancet Oncol, JAMA, JAMA Intern Med, JAMA Oncol, BMJ, Ann Intern Med, J Clin Oncol, Ann Oncol, Eur J Cancer, Br J Cancer, Cancer

対象期間:2018年12月〜2019年2月刊行分

いわゆる“トップジャーナル”に掲載された緩和ケアに関する最新論文を広く紹介します。


【N Engl J Med. 2018;379(23-26), 2019;380(1-9)】
1.高齢者での物質使用障害の総説
Lehmann SW, Fingerhood M. Substance-Use Disorders in Later Life. N Engl J Med. 2018;379(24):2351-60.[PMID: 30575463]
2.がんサバイバーシップの総説
Shapiro CL. Cancer Survivorship. N Engl J Med. 2018;379(25):2438-50. [PMID: 30575480]
3.ICU でのせん妄に対するハロペリドールとジプラシドンのRCT
Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, et al. Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. N Engl J Med. 2018;379(26):2506-16. [PMID: 30346242]
4.オピオイド鎮痛薬使用、過剰摂取、自殺の関連に関する総説(Review Article)
Bohnert ASB, Ilgen MA. Understanding Links among Opioid Use, Overdose, and Suicide. N Engl J Med. 2019;380(1):71-9. [PMID: 30601750]
5.重症疾患でのオピオイド鎮痛薬耐性に関する総説(Review Article)
Martyn JAJ, Mao J, Bittner EA. Opioid Tolerance in Critical Illness. N Engl J Med. 2019;380(4):365-78. [PMID: 30673555]
6.がん患者の静脈血栓症に対するアピキサバンの有効性と安全性のRCT
Carrier M, Abou-Nassar K, Mallick R, Tagalakis V, Shivakumar S, Schattner A, et al. Apixaban to Prevent Venous Thromboembolism in Patients with Cancer. N Engl J Med. 2019;380(8):711-9. [PMID: 30511879]
7.外来がん患者の静脈血栓症に対するリバーロキサバンの有効性と安全性に関する RCT
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, et al. Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer. N Engl J Med. 2019;380(8):720-8. [PMID: 30786186]

【Lancet. 2018;392(10162-10165); 2019;393(10166-10173)】
8.オピオイド鎮痛薬使用障害に対する毎月のブプレノルフィン持効性注射の有効性と安全性に関するRCT
Haight BR, Learned SM, Laffont CM, Fudala PJ, Zhao Y, Garofalo AS, et al. Efficacy and safety of a monthly buprenorphine depot injection for opioid use disorder: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2019;393(10173):778-90. [PMID: 30792007]

【Lancet Oncol. 2018;19(9-11)】
9.小児・AYA世代がんでのがん治療関連内耳障害の動向調査の臨床ガイドライン
Clemens E, van den Heuvel-Eibrink MM, Mulder RL, Kremer LCM, Hudson MM, Skinner R, et al. Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium. Lancet Oncol. 2019;20(1):e29-e41.[PMID: 30614474]
10.がん治療関連認知機能障害治療の薬理
Karschnia P, Parsons MW, Dietrich J. Pharmacologic management of cognitive impairment induced by cancer therapy. Lancet Oncol. 2019;20(2):e92-e102.[PMID: 30723041]

【JAMA. 2018;320(21-24), 2019;321(1-8)】
11.非がん性疼痛に対するオピオイド鎮痛薬の有効性の系統的レビュー
Busse JW, Wang L, Kamaleldin M, Craigie S, Riva JJ, Montoya L, et al. Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis. JAMA. 2018;320(23):2448-60. [PMID: 30561481]
12.米国FDAの医薬品リスク評価の規制による経粘膜即放性フェンタニル不適切使用への影響
Rollman JE, Heyward J, Olson L, Lurie P, Sharfstein J, Alexander GC. Assessment of the FDA Risk Evaluation and Mitigation Strategy for Transmucosal Immediate-Release Fentanyl Products. JAMA. 2019;321(7):676-85.[PMID: 30778596]

【JAMA Intern Med. 2018;178(12), 2019;179(1-2)】
13.がん臨床試験での無憎悪生存期間とQOLの関連に関する系統的レビュー
Kovic B, Jin X, Kennedy SA, Hylands M, Pedziwiatr M, Kuriyama A, et al. Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology: A Systematic Review and Quantitative Analysis. JAMA Intern Med. 2018;178(12):1586-96.[PMID: 30285081]
14.プレガバリンの臨床試験の有効性の症状別の検討:系統的レビュー
Sheppard JP, Stevens S, Stevens R, Martin U, Mant J, Hobbs FDR, et al. Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension. JAMA Intern Med. 2018;178(12):1626-34.[PMID:30477010]
15.米国の若年患者に対する歯科医によるオピオイド鎮痛薬処方と使用障害の関連
Schroeder AR, Dehghan M, Newman TB, Bentley JP, Park KT. Association of Opioid Prescriptions From Dental Clinicians for US Adolescents and Young Adults With Subsequent Opioid Use and Abuse. JAMA Intern Med. 2019;179(2):145-52.[PMID: 30508022]
16.末期腎不全での定期的な維持透析と緊急透析のみでの予後と医療比の比較
Nguyen OK, Vazquez MA, Charles L, Berger JR, Quinones H, Fuquay R, et al. Association of Scheduled vs Emergency-Only Dialysis With Health Outcomes and Costs in Undocumented Immigrants With End-stage Renal Disease. JAMA Intern Med. 2019;179(2):175-83.[PMID: 30575859]
17.せん妄評価指標の系統的レビュー
Jones RN, Cizginer S, Pavlech L, Albuquerque A, Daiello LA, Dharmarajan K, et al. Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review. JAMA Intern Med. 2019;179(2):231-9.[PMID:30556827]

【JAMA Oncol. 2018;4(12), 2019;5(1-2)】
18.進行がん患者の緩和ケアアウトカムに対する患者ナビゲーターの無作為化比較試験
Fischer SM, Kline DM, Min SJ, Okuyama-Sasaki S, Fink RM. Effect of Apoyo con Carino (Support With Caring) Trial of a Patient Navigator Intervention to Improve Palliative Care Outcomes for Latino Adults With Advanced Cancer: A Randomized Clinical Trial. JAMA Oncol. 2018;4(12):1736-41.[PMID: 30326035]

【BMJ 2018;363(8178-8180), 2019;364(8181-8188);】
19.米国のかかりつけ医の患者への病状説明と意思決定の話し合いの時間
Caverly TJ, Hayward RA, Burke JF. Much to do with nothing: microsimulation study on time management in primary care. BMJ. 2018;363:k4983. [PMID: 30545899]
20.肺がんでのBest Supportive Careの新しいモデル(Comment)
Bowden J, Fenning S, Marron B, Macpherson C, Boyce S, Wardrope V, et al. Best supportive care in advanced lung cancer-more than a label? BMJ. 2018;363:k5017. [PMID:30591556]

【Ann Intern Med. 2018;169(11-12), 2019;170(1-4)】
21.患者・家族のパートナーシップ(医療への参加)の原則に関する米国内科学会の声明(Position papers)
Nickel WK, Weinberger SE, Guze PA, Patient Partnership in Healthcare Committee of the American College of P. Principles for Patient and Family Partnership in Care: An American College of Physicians Position Paper. Ann Intern Med. 2018;169(11):796-9. [PMID: 30476985]
22.米国の2006〜2015年のオピオイド鎮痛薬処方での疼痛の種類と併存疾患(Letters)
Sherry TB, Sabety A, Maestas N. Documented Pain Diagnoses in Adults Prescribed Opioids: Results From the National Ambulatory Medical Care Survey, 2006-2015. Ann Intern Med. 2018;169(12):892-4. [PMID: 30208400]
23.オピオイド鎮痛薬関連の尿閉にナルブフィンが奏効した症例報告(Letters)
Ibrahim AM, Obaidi Z, Ruan G, Adaramola D, Onguti S. Nalbuphine for Opioid-Induced Urine Retention. Ann Intern Med. 2018;169(12):894-5. [PMID: 30178006]

【J Clin Oncol. 2018;36(34-37), 2019;37(1-6)】
24.転移性脊椎圧迫患者のアセスメントと治療のレビュー
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, et al. Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review. J Clin Oncol. 2019;37(1):61-71.[PMID: 30395488]
25.頭頚部がん患者の放射線治療関連神経障害性疼痛に対するプレガバリンの無作為化比較試験
Jiang J, Li Y, Shen Q, Rong X, Huang X, Li H, et al. Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial. J Clin Oncol. 2019;37(2):135-43.[PMID: 30457920]

【Ann Oncol. 2018;29(12), 2019;30(1-2)】
26.入院がん患者に対する症状モニタリングの通知システム介入の無作為化比較試験
Nipp RD, El-Jawahri A, Ruddy M, Fuh C, Temel B, D'Arpino SM, et al. Pilot randomized trial of an electronic symptom monitoring intervention for hospitalized patients with cancer. Ann Oncol. 2019;30(2):274-80.[PMID: 30395144]

【Eur J Cancer. 2018;105, 2019;106-108】
27.採血データとバイタルサインによる進行がん患者の予後予測
Hamano J, Takeuchi A, Yamaguchi T, Baba M, Imai K, Ikenaga M, et al. A combination of routine laboratory findings and vital signs can predict survival of advanced cancer patients without physician evaluation: a fractional polynomial model. Eur J Cancer. 2018;105:50-60.[PMID: 30391780]
28.がん患者の侵害受容性疼痛と混合性疼痛でのオピオイド鎮痛薬の有効性の比較
Bechakra M, Moerdijk F, van Rosmalen J, Koch BCP, van der Rijt CCD, Sillevis Smitt PAE, et al. Opioid responsiveness of nociceptive versus mixed pain in clinical cancer patients. Eur J Cancer. 2018;105:79-87.[PMID:30439627]

【Br J Cancer. 2018;119(12), 2019;120(1-4)】
なし

【Cancer. 2018;124(23-24), 2019;125(1-4)】
29.進行がん患者の喫煙と痛みの関連
Dev R, Kim YJ, Reddy A, Hui D, Tanco K, Liu D, et al. Association between tobacco use, pain expression, and coping strategies among patients with advanced cancer. Cancer. 2019;125(1):153-60.[PMID: 30351502]
30.小児がん診断後5か月での親の苦痛と心理社会的リスクとの関連
Schepers SA, Sint Nicolaas SM, Maurice-Stam H, Haverman L, Verhaak CM, Grootenhuis MA. Parental distress 6 months after a pediatric cancer diagnosis in relation to family psychosocial risk at diagnosis. Cancer. 2018;124(2):381-90.[PMID: 28902391]
31.AYA世代がん患者の性機能の2年間の推移
Acquati C, Zebrack BJ, Faul AC, Embry L, Aguilar C, Block R, et al. Sexual functioning among young adult cancer patients: A 2-year longitudinal study. Cancer. 2018;124(2):398-405.[PMID: 29149503]
32.がん患者のPTSDと心理的苦痛の4年間での推移と関連要因
Chan CMH, Ng CG, Taib NA, Wee LH, Krupat E, Meyer F. Course and predictors of post-traumatic stress disorder in a cohort of psychologically distressed patients with cancer: A 4-year follow-up study. Cancer. 2018;124(2):406-16.[PMID: 29152719]
33.小児非ホジキンリンパ腫の成人サバイバーの認知機能、心理症状、QOL
Ehrhardt MJ, Mulrooney DA, Li C, Baassiri MJ, Bjornard K, Sandlund JT, et al. Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma. Cancer. 2018;124(2):417-25.[PMID: 28915338]
34.進行期肺がん患者のホスピス利用の変化
Sullivan DR, Ganzini L, Lapidus JA, Hansen L, Carney PA, Osborne ML, et al. Improvements in hospice utilization among patients with advanced-stage lung cancer in an integrated health care system. Cancer. 2018;124(2):426-33.[PMID: 29023648]
35.アンドロゲン抑制療法中の前立腺がん患者の睡眠障害
Gonzalez BD, Small BJ, Cases MG, Williams NL, Fishman MN, Jacobsen PB, et al. Sleep disturbance in men receiving androgen deprivation therapy for prostate cancer: The role of hot flashes and nocturia. Cancer. 2018;124(3):499-506.[PMID: 29072790]
36.がん関連倦怠感に対するマッサージの無作為化比較試験
Kinkead B, Schettler PJ, Larson ER, Carroll D, Sharenko M, Nettles J, et al. Massage therapy decreases cancer-related fatigue: Results from a randomized early phase trial. Cancer. 2018;124(3):546-54.[PMID: 29044466]
37.高齢がん患者のQOLの関連要因
Pisu M, Azuero A, Halilova KI, Williams CP, Kenzik KM, Kvale EA, et al. Most impactful factors on the health-related quality of life of a geriatric population with cancer. Cancer. 2018;124(3):596-605.[PMID: 29250775]
38.非小細胞肺がん患者の悪液質に対するアナモレリンの二重盲検無作為化比較試験
Katakami N, Uchino J, Yokoyama T, Naito T, Kondo M, Yamada K, et al. Anamorelin (ONO-7643) for the treatment of patients with non-small cell lung cancer and cachexia: Results from a randomized, double-blind, placebo-controlled, multicenter study of Japanese patients (ONO-7643-04). Cancer. 2018;124(3):606-16.[PMID: 29205286]
39.小児白血病患者の長期サバイバーのダウン症併存の有無での健康状態の比較
Goldsby RE, Stratton KL, Raber S, Ablin A, Strong LC, Oeffinger K, et al. Long-term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report. Cancer. 2018;124(3):617-25.[PMID: 29105081]
40.日本の医師の緩和ケアの知識と困難感の2008年と2015年の比較
Nakazawa Y, Yamamoto R, Kato M, Miyashita M, Kizawa Y, Morita T. Improved knowledge of and difficulties in palliative care among physicians during 2008 and 2015 in Japan: Association with a nationwide palliative care education program. Cancer. 2018;124(3):626-35.[PMID: 29023634]
41.高齢大腸がん患者での治療ガイドラインの順守
Zhao H, Zhang N, Ho V, Ding M, He W, Niu J, et al. Adherence to treatment guidelines and survival for older patients with stage II or III colon cancer in Texas from 2001 through 2011. Cancer. 2018;124(4):679-87.[PMID: 29140558]
42.乳がん補助化学療法中の倦怠感と身体活動の関連
Manneville F, Rotonda C, Conroy T, Bonnetain F, Guillemin F, Omorou AY. The impact of physical activity on fatigue and quality of life during and after adjuvant treatment for breast cancer. Cancer. 2018;124(4):797-806.[PMID: 29116645]
43.評価ツールPROMISによる造血幹細胞移植後の長期サバイバーの症状アセスメント
Shaw BE, Syrjala KL, Onstad LE, Chow EJ, Flowers ME, Jim H, et al. PROMIS measures can be used to assess symptoms and function in long-term hematopoietic cell transplantation survivors. Cancer. 2018;124(4):841-9.[PMID: 29072787]
44.成人発症リンパ腫の長期サバイバーのアントラサイクリン関連心機能障害の発症率
Armenian SH, Mertens L, Slorach C, Venkataraman K, Mascarenhas K, Nathwani N, et al. Prevalence of anthracycline-related cardiac dysfunction in long-term survivors of adult-onset lymphoma. Cancer. 2018;124(4):850-7.[PMID: 29112235]
45.無作為化比較試験の有害事象データからの治療毒性の推定
Lee SM, Hershman DL, Miao J, Zhong X, Unger JM, Cheung YKK. Estimating global treatment toxicity burden from adverse-event data. Cancer. 2018;124(4):858-64.[PMID: 29112232]

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