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Japanese Society for Palliative Medicine
News Letter No.81
日本緩和医療学会ニューズレター
Nov 2018  81
Journal Watch
緩和ケアに関する論文レビュー
名古屋大学大学院医学系研究科 看護学専攻基礎・臨床看護学講座  佐藤 一樹
対象雑誌:N Engl J Med, Lancet, Lancet Oncol, JAMA, JAMA Intern Med, JAMA Oncol, BMJ, Ann Intern Med, J Clin Oncol, Ann Oncol, Eur J Cancer, Br J Cancer, Cancer

対象期間:2018年6月〜8月刊行分

いわゆる“トップジャーナル”に掲載された緩和ケアに関する最新論文を広く紹介します。


【N Engl J Med. 2018;378(23-26), 379(1-9)】
1.ICU での家族支援の無作為化比較試験
White DB, Angus DC, Shields AM, Buddadhumaruk P, Pidro C, Paner C, et al. A Randomized Trial of a Family-Support Intervention in Intensive Care Units. N Engl J Med. 2018;378(25):2365-75. [PMID:29791247]
2.シスプラチン誘発性聴覚障害予防に対するチオ硫酸ナトリウムの無作為化比較試験
Brock PR, Maibach R, Childs M, Rajput K, Roebuck D, Sullivan MJ, et al. Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss. N Engl J Med. 2018;378(25):2376-85. [PMID: 29924955]
オピオイド鎮痛薬使用障害に関する総説5編
3.オピオイド鎮痛薬使用障害でのブプレノルフィン漸減療法の誤解と真実(Perspective)
Wakeman SE, Barnett ML. Primary Care and the Opioid-Overdose Crisis - Buprenorphine Myths and Realities. N Engl J Med. 2018;379(1):1-4. [PMID: 29972748]
4.オピオイド鎮痛薬使用障害でのブプレノルフィン漸減療法の総説(Perspective)
Saloner B, Stoller KB, Alexander GC. Moving Addiction Care to the Mainstream - Improving the Quality of Buprenorphine Treatment. N Engl J Med. 2018;379(1):4-6. [PMID: 29972745]
5.オピオイド鎮痛薬使用障害でのメサドン漸減療法の総説(Perspective)
Samet JH, Botticelli M, Bharel M. Methadone in Primary Care - One Small Step for Congress, One Giant Leap for Addiction Treatment. N Engl J Med. 2018;379(1):7-8. [PMID: 29972744]
6.薬物乱用の新しい潮流-FDA の医薬品安全対策監視(Perspective)
Throckmorton DC, Gottlieb S, Woodcock J. The FDA and the Next Wave of Drug Abuse - Proactive Pharmacovigilance. N Engl J Med. 2018;379(3):205-7. [PMID: 29847203]
7.急性疼痛のオピオイド鎮痛薬処方の制限(Perspective)
Lowenstein M, Grande D, Delgado MK. Opioid Prescribing Limits for Acute Pain - Striking the Right Balance. N Engl J Med. 2018;379(6):504-6. [PMID: 30089064]
8.非経口オピオイド鎮痛薬の不足-オピオイド過剰摂取時代の疼痛治療
Bruera E. Parenteral Opioid Shortage-Treating Pain during the Opioid-Overdose Epidemic. N Engl J Med. 2018;379(7):601-3. [PMID: 30020849]


【Lancet. 2017; 2018;391(10136-10148)】
なし


【Lancet Oncol. 2018;19(6-8)】
9.中枢神経系原発悪性リンパ腫診断時の認知機能と健康関連QOLのシステマティックレビュー
van der Meulen M, Dirven L, Habets EJJ, van den Bent MJ, Taphoorn MJB, Bromberg JEC. Cognitive functioning and health-related quality of life in patients with newly diagnosed primary CNS lymphoma: a systematic review. Lancet Oncol. 2018;19(8):e407-e18. [PMID: 30102235]


【JAMA. 2018;319(21-24), 320(1-8)】
10.早期乳がん患者のアロマターゼ阻害薬に関連した関節痛に対する鍼治療の無作為化比較試験
Hershman DL, Unger JM, Greenlee H, Capodice JL, Lew DL, Darke AK, et al. Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast Cancer: A Randomized Clinical Trial. JAMA. 2018;320(2):167-76. [PMID: 29998338]
11. 外科手術退院後のオピオイド過剰摂取(Letter)
Ladha KS, Gagne JJ, Patorno E, Huybrechts KF, Rathmell JP, Wang SV, et al. Opioid Overdose After Surgical Discharge. JAMA. 2018;320(5):502-4. [PMID: 30087999]
12. 親知らず抜歯後のオピオイド処方の長期間の継続
Harbaugh CM, Nalliah RP, Hu HM, Englesbe MJ, Waljee JF, Brummett CM. Persistent Opioid Use After Wisdom Tooth Extraction. JAMA. 2018;320(5):504-6. [PMID: 30088000]


【JAMA Intern Med. 2018;178(3-5)】
13.オピオイドの経口・皮下投与を推奨する医療者教育によるオピオイド静脈投与の変化
Ackerman AL, O'Connor PG, Doyle DL, Marranca SM, Haight CL, Day CE, et al. Association of an Opioid Standard of Practice Intervention With Intravenous Opioid Exposure in Hospitalized Patients. JAMA Intern Med. 2018;178(6):759-63. [PMID: 29799964]
14.オピオイド使用障害に対するブプレノルフィン舌下(ナロキソン含有)とブプレノルフィン皮下デバイスの無作為化比較試験
Lofwall MR, Walsh SL, Nunes EV, Bailey GL, Sigmon SC, Kampman KM, et al. Weekly and Monthly Subcutaneous Buprenorphine Depot Formulations vs Daily Sublingual Buprenorphine With Naloxone for Treatment of Opioid Use Disorder: A Randomized Clinical Trial. JAMA Intern Med. 2018;178(6):764-73. [PMID: 29799968]
15.維持透析を受けた終末期患者でのホスピス利用期間と終末期医療とその医療費の関連
Wachterman MW, Hailpern SM, Keating NL, Kurella Tamura M, O'Hare AM. Association Between Hospice Length of Stay, Health Care Utilization, and Medicare Costs at the End of Life Among Patients Who Received Maintenance Hemodialysis. JAMA Intern Med. 2018;178(6):792-9. [PMID: 29710217]
16.入院患者に対する緩和ケアの医療経済評価のメタ分析
May P, Normand C, Cassel JB, Del Fabbro E, Fine RL, Menz R, et al. Economics of Palliative Care for Hospitalized Adults With Serious Illness: A Meta-analysis. JAMA Intern Med. 2018;178(6):820-9. [PMID: 29710177]
17.高齢者に対する心理介入の慢性痛への効果のメタ分析
Niknejad B, Bolier R, Henderson CR, Jr. , Delgado D, Kozlov E, Lockenhoff CE, et al. Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-analysis. JAMA Intern Med. 2018;178(6):830-9. [PMID: 29801109]
18.ナーシングホームの認知症高齢者に対する予後予測の正確性と予後予測と積極治療との関連
Loizeau AJ, Shaffer ML, Habtemariam DA, Hanson LC, Volandes AE, Mitchell SL. Association of Prognostic Estimates With Burdensome Interventions in Nursing Home Residents With Advanced Dementia. JAMA Intern Med. 2018;178(7):922-9. [PMID: 29813159]
19.患者・医療者間コミュニケーション促進介入による治療目標話し合いの患者評価への効果:無作為化比較試験
Curtis JR, Downey L, Back AL, Nielsen EL, Paul S, Lahdya AZ, et al. Effect of a Patient and Clinician Communication-Priming Intervention on Patient-Reported Goals-of-Care Discussions Between Patients With Serious Illness and Clinicians: A Randomized Clinical Trial. JAMA Intern Med. 2018;178(7):930-40. [PMID: 29802770]
20.ナーシングホームの認知症高齢者に対するACP映像支援ツールの無作為化比較試験
Mitchell SL, Shaffer ML, Cohen S, Hanson LC, Habtemariam D, Volandes AE. An Advance Care Planning Video Decision Support Tool for Nursing Home Residents With Advanced Dementia: A Cluster Randomized Clinical Trial. JAMA Intern Med. 2018;178(7):961-9. [PMID: 29868778]
21.透析を受ける終末期腎不全患者での下肢切断の2000年〜2014年の推移
Franz D, Zheng Y, Leeper NJ, Chandra V, Montez-Rath M, Chang TI. Trends in Rates of Lower Extremity Amputation Among Patients With End-stage Renal Disease Who Receive Dialysis. JAMA Intern Med. 2018;178(8):1025-32. [PMID: 29987332]


【JAMA Oncol. 2018;4(6-8)】
22.大腸がんサバイバーでの栄養と身体活動のASCOガイドラインの遵守と予後との関連
Van Blarigan EL, Fuchs CS, Niedzwiecki D, Zhang S, Saltz LB, Mayer RJ, et al. Association of Survival With Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors After Colon Cancer Diagnosis: The CALGB 89803/Alliance Trial. JAMA Oncol. 2018;4(6):783-90. [PMID: 29710284]
23.がん患者の神経障害性疼痛に対する経口ケタミンのプラセボ対照無作為化比較試験(短報)
Fallon MT, Wilcock A, Kelly CA, Paul J, Lewsley LA, Norrie J, et al. Oral Ketamine vs Placebo in Patients With Cancer-Related Neuropathic Pain: A Randomized Clinical Trial. JAMA Oncol. 2018;4(6):870-2. [PMID: 29621378]
24.緩和ケア外来時の医師のコンピュータ使用の有無による医師の共感、コミュニケーションスキル、職業意識に関する患者評価への影響:映像資料を用いた無作為化比較試験
Haider A, Tanco K, Epner M, Azhar A, Williams J, Liu DD, et al. Physicians' Compassion, Communication Skills, and Professionalism With and Without Physicians' Use of an Examination Room Computer: A Randomized Clinical Trial. JAMA Oncol. 2018;4(6):879-81. [PMID: 29710136.]
25.初期治療後の限局性前立腺がん患者の喫煙と予後の関連
Foerster B, Pozo C, Abufaraj M, Mari A, Kimura S, D'Andrea D, et al. Association of Smoking Status With Recurrence, Metastasis, and Mortality Among Patients With Localized Prostate Cancer Undergoing Prostatectomy or Radiotherapy: A Systematic Review and Meta-analysis. JAMA Oncol. 2018;4(7):953-61. [PMID: 29800115]


【BMJ 2018;360(8155-8164)】
26.オピオイド処方の法的規制によるインターネットでの違法なオピオイド販売への影響
Martin J, Cunliffe J, Decary-Hetu D, Aldridge J. Effect of restricting the legal supply of prescription opioids on buying through online illicit marketplaces: interrupted time series analysis. BMJ. 2018;361:k2270. [PMID: 29899119.]
27.肝硬変と肝臓がんによる死亡の推移:米国での1999年〜2016年の疫学調査
Tapper EB, Parikh ND. Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study. BMJ. 2018;362:k2817. [PMID: 30021785]
28.米国でのオピオイド処方の2007年〜2016年の推移と医療保険の種別による比較
Jeffery MM, Hooten WM, Henk HJ, Bellolio MF, Hess EP, Meara E, et al. Trends in opioid use in commercially insured and Medicare Advantage populations in 2007-16: retrospective cohort study. BMJ. 2018;362:k2833. [PMID: 30068513]


【Ann Intern Med. 2018;168(11-12), 169(1-4)】
29.処方モニタリングシステムと薬物乱用の関連のレビュー
Fink DS, Schleimer JP, Sarvet A, Grover KK, Delcher C, Castillo-Carniglia A, et al. Association Between Prescription Drug Monitoring Programs and Nonfatal and Fatal Drug Overdoses: A Systematic Review. Ann Intern Med. 2018;168(11):783-90. [PMID: 29801093]
30.米国のオピオイド乱用:2008年から2012年の推移
Carey CM, Jena AB, Barnett ML. Patterns of Potential Opioid Misuse and Subsequent Adverse Outcomes in Medicare, 2008 to 2012. Ann Intern Med. 2018;168(12):837-45. [PMID: 29800019]
31.オピオイド使用障害の薬物療法と予後
Larochelle MR, Bernson D, Land T, Stopka TJ, Wang N, Xuan Z, et al. Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality: A Cohort Study. Ann Intern Med. 2018;169(3):137-45. [PMID: 29913516]
32.オピオイドの添付文書での保管と破棄方法の記載の比較(Letters)
Doucette ML, Shields WC, Haring RS, Frattaroli S. Storing and Disposing of Opioid Analgesics: What Does Our Medicine Tell Us? Ann Intern Med. 2018;169(3):198-9. [PMID: 29710198]


【Ann Oncol. 2018;29(6-8)】
33.オピオイド誘発性便秘に対するナルデメジンのQOLへの効果:第V相無作為化比較試験の2次解析
Katakami N, Harada T, Murata T, Shinozaki K, Tsutsumi M, Yokota T, et al. Randomized phase 3 and extension studies: Efficacy and impacts on quality of life of naldemedine in subjects with opioid-induced constipation and cancer. Ann Oncol. 2018;29(6):1461-7. [PMID: 29912271]
34.閉経後女性の経口ビスホスフォネート使用の肺がんリスク
Tao MH, Chen S, Freudenheim JL, Cauley JA, Johnson KC, Mai X, et al. Oral bisphosphonate use and lung cancer incidence among postmenopausal women. Ann Oncol. 2018;29(6):1476-85. [PMID: 29617712]
35.高催吐性化学療法でのNEPA注射薬(ホスネツピタントとパロトセトロンの新規制吐剤)の第V相安全性試験
Schwartzberg L, Roeland E, Andric Z, Kowalski D, Radic J, Voisin D, et al. Phase III safety study of intravenous NEPA: a novel fixed antiemetic combination of fosnetupitant and palonosetron in patients receiving highly emetogenic chemotherapy. Ann Oncol. 2018;29(7):1535-40. [PMID: 29722791]
36.高齢がん患者のQOLニード:国際老年腫瘍学会SIOG臨床ガイドライン
Scotte F, Bossi P, Carola E, Cudennec T, Dielenseger P, Gomes F, et al. Addressing the quality of life needs of older patients with cancer: a SIOG consensus paper and practical guide. Ann Oncol. 2018;29(8):1718-26. [PMID: 30010772]


【Eur J Cancer. 2018;96-99】
なし


【Br J Cancer. 2018;118(11-12), 119(1-5)】
37.放射線治療を受ける乳がん患者に対する放射線治療士による教育介入の精神的苦痛に対する効果
Halkett G, O'Connor M, Jefford M, Aranda S, Merchant S, Spry N, et al. RT Prepare: a radiation therapist-delivered intervention reduces psychological distress in women with breast cancer referred for radiotherapy. Br J Cancer. 2018;118(12):1549-58. [PMID: 29855611]
38.乳がん化学療法中の不眠に対する簡易行動療法の第U相無作為化比較試験
Palesh O, Scheiber C, Kesler S, Janelsins MC, Guido JJ, Heckler C, et al. Feasibility and acceptability of brief behavioral therapy for cancer-related insomnia: effects on insomnia and circadian rhythm during chemotherapy: a phase II randomised multicentre controlled trial. Br J Cancer. 2018;119(3):274-81. [PMID: 30026614]


【Cancer. 2018;124(11-16)】
39.小児がん患者の緩和ケア受診の障害に関するレビュー
Haines ER, Frost AC, Kane HL, Rokoske FS. Barriers to accessing palliative care for pediatric patients with cancer: A review of the literature. Cancer. 2018;124(11):2278-88. [PMID: 29451689]
40.化学療法誘発性末梢神経障害に関する総説
Ma J, Kavelaars A, Dougherty PM, Heijnen CJ. Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source. Cancer. 2018;124(11):2289-98. [PMID: 29461625]
41.乳がんサバイバーケアに関する人種間格差
Olagunju TO, Liu Y, Liang LJ, Stomber JM, Griggs JJ, Ganz PA, et al. Disparities in the survivorship experience among Latina survivors of breast cancer. Cancer. 2018;124(11):2373-80. [PMID: 29624633]
42.がん患者の精神疾患のBrief Symptom Inventoryによるスクリーニングの精度
Grassi L, Caruso R, Mitchell AJ, Sabato S, Nanni MG. Screening for emotional disorders in patients with cancer using the Brief Symptom Inventory (BSI) and the BSI-18 versus a standardized psychiatric interview (the World Health Organization Composite International Diagnostic Interview). Cancer. 2018;124(11):2415-26. [PMID: 29660109]
43.造血幹細胞移植後サバイバーの性機能に対する複合介入の予備的試験
El-Jawahri A, Fishman SR, Vanderklish J, Dizon DS, Pensak N, Traeger L, et al. Pilot study of a multimodal intervention to enhance sexual function in survivors of hematopoietic stem cell transplantation. Cancer. 2018;124(11):2438-46. [PMID: 29537491]
44.男性小児がん長期サバイバーの不妊リスクの認識
Gilleland Marchak J, Seidel KD, Mertens AC, Ritenour CWM, Wasilewski-Masker K, Leisenring WM, et al. Perceptions of risk of infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer. 2018;124(11):2447-55. [PMID: 29663341]
45.米国のがん性疼痛治療のオピオイド危機に関する総説
Paice JA. Cancer pain management and the opioid crisis in America: How to preserve hard-earned gains in improving the quality of cancer pain management. Cancer. 2018;124(12):2491-7. [PMID: 29499072]
46.転移性乳がん患者での治療前運動療法の無作為化比較試験
Scott JM, Iyengar NM, Nilsen TS, Michalski M, Thomas SM, Herndon J, 2nd, et al. Feasibility, safety, and efficacy of aerobic training in pretreated patients with metastatic breast cancer: A randomized controlled trial. Cancer. 2018;124(12):2552-60. [PMID: 29624641]
47.大腸がんの進行度と宗教的信念やスピリチュアルな信念との関連
Polite BN, Cipriano-Steffens TM, Hlubocky FJ, Jean-Pierre P, Cheng Y, Brewer KC, et al. Association of externalizing religious and spiritual beliefs on stage of colon cancer diagnosis among black and white multicenter urban patient populations. Cancer. 2018;124(12):2578-87. [PMID: 29579340]
48.大腸がん患者の不安と抑うつ症状の有症率、予測因子、QOLへの影響に関する大規模調査
Mols F, Schoormans D, de Hingh I, Oerlemans S, Husson O. Symptoms of anxiety and depression among colorectal cancer survivors from the population-based, longitudinal PROFILES Registry: Prevalence, predictors, and impact on quality of life. Cancer. 2018;124(12):2621-8. [PMID: 29624635]
49.米国のがんサバイバーの多剤併用
Murphy CC, Fullington HM, Alvarez CA, Betts AC, Lee SJC, Haggstrom DA, et al. Polypharmacy and patterns of prescription medication use among cancer survivors. Cancer. 2018;124(13):2850-7. [PMID: 29645083]
50.血液がんサバイバーの医療資源利用と心理的苦痛:一般市民との比較
Arts LPJ, Oerlemans S, Tick L, Koster A, Roerdink HTJ, van de Poll-Franse LV. More frequent use of health care services among distressed compared with nondistressed survivors of lymphoma and chronic lymphocytic leukemia: Results from the population-based PROFILES registry. Cancer. 2018;124(14):3016-24. [PMID: 29698556]
51.フランスの進行期肺がん患者での緩和ケア導入時期と終末期の積極治療との関連
Goldwasser F, Vinant P, Aubry R, Rochigneux P, Beaussant Y, Huillard O, et al. Timing of palliative care needs reporting and aggressiveness of care near the end of life in metastatic lung cancer: A national registry-based study. Cancer. 2018;124(14):3044-51. [PMID: 29742292]
52.高齢膀胱がん患者の精神疾患併存と予後との関連
Jazzar U, Yong S, Klaassen Z, Huo J, Hughes BD, Esparza E, et al. Impact of psychiatric illness on decreased survival in elderly patients with bladder cancer in the United States. Cancer. 2018;124(15):3127-35. [PMID: 29660813]
53.進行がん患者の精神的・実存的苦痛に対する意味を中心とした個人精神療法の無作為化比較試験
Breitbart W, Pessin H, Rosenfeld B, Applebaum AJ, Lichtenthal WG, Li Y, et al. Individual meaning-centered psychotherapy for the treatment of psychological and existential distress: A randomized controlled trial in patients with advanced cancer. Cancer. 2018;124(15):3231-9. [PMID: 29757459]
54.高齢がん患者の聴覚障害や視覚障害と身体機能、不安・抑うつ、認知機能との関連
Soto-Perez-de-Celis E, Sun CL, Tew WP, Mohile SG, Gajra A, Klepin HD, et al. Association between patient-reported hearing and visual impairments and functional, psychological, and cognitive status among older adults with cancer. Cancer. 2018;124(15):3249-56. [PMID: 29797664]
55.陽子線治療を受けた小児髄芽腫サバイバーの治療後5年間のQOL
Kamran SC, Goldberg SI, Kuhlthau KA, Lawell MP, Weyman EA, Gallotto SL, et al. Quality of life in patients with proton-treated pediatric medulloblastoma: Results of a prospective assessment with 5-year follow-up. Cancer. 2018;124(16):3390-400. [PMID: 29905942]
56.卵巣がん患者の診断後すぐの生活のストレスと診断後1年間の不安とホルモン分泌との関連
Armer JS, Clevenger L, Davis LZ, Cuneo M, Thaker PH, Goodheart MJ, et al. Life stress as a risk factor for sustained anxiety and cortisol dysregulation during the first year of survivorship in ovarian cancer. Cancer. 2018;124(16):3401-8. [PMID: 29905941]
57.がん医療の適時性の都会と田舎での比較
Mollica MA, Weaver KE, McNeel TS, Kent EE. Examining urban and rural differences in perceived timeliness of care among cancer patients: A SEER-CAHPS study. Cancer. 2018;124(15):3257-65. [PMID: 29878305]

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