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Japanese Society for Palliative Medicine
News Letter No.76
日本緩和医療学会ニューズレター
Aug 2017  76
Journal Watch
緩和ケアに関する論文レビュー
名古屋大学大学院 医学系研究科 看護学専攻 基礎・臨床看護学講座  佐藤 一樹
対象雑誌:N Engl J Med, Lancet, Lancet Oncol, JAMA, JAMA Intern Med, BMJ, Ann Intern Med, J Clin Oncol, Ann Oncol, Eur J Cancer, Br J Cancer, Cancer

対象期間:2017年3月〜5月刊行分

いわゆる“トップジャーナル”に掲載された緩和ケアに関する最新論文を広く紹介します。

【N Engl J Med. 2017;376(9-21)】
1.坐骨神経痛に対するプレガバリンの臨床試験

Mathieson S, Maher CG, McLachlan AJ, Latimer J, Koes BW, Hancock MJ, et al. Trial of Pregabalin for Acute and Chronic Sciatica. N Engl J Med. 2017;376(12):1111-20. PMID 28328324.
2.ベンゾジアゼピン依存の治療の総説
Soyka M. Treatment of Benzodiazepine Dependence. N Engl J Med. 2017;376(12):1147-57. PMID 28328330.
3.がん患者の急性腎障害のレビュー
Rosner MH, Perazella MA. Acute Kidney Injury in Patients with Cancer. N Engl J Med. 2017;376(18):1770-81. PMID 28467867.

【Lancet. 2017;389(10072-10084)】
4.脳卒中後の失語に対する集中言語訓練の無作為化比較試験

Breitenstein C, Grewe T, Floel A, Ziegler W, Springer L, Martus P, et al. Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blinded-endpoint, controlled trial in a health-care setting. Lancet. 2017;389(10078):1528-38. PMID 28256356.
5.中国の85歳以上高齢者の予後、ADL、身体・認知機能
Zeng Y, Feng Q, Hesketh T, Christensen K, Vaupel JW. Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet. 2017;389(10079):1619-29. PMID 28285816.

【Lancet Oncol. 2017;18(3-5)】
6.がん患者対象のQOL調査の応諾率に関するレビュー

Wakefield CE, Fardell JE, Doolan EL, Aaronson NK, Jacobsen PB, Cohn RJ, et al. Participation in psychosocial oncology and quality-of-life research: a systematic review. Lancet Oncol. 2017;18(3):e153-e65. PMID 28271870.
7.東地中海沿岸諸国での緩和ケアの現状と課題
Fadhil I, Lyons G, Payne S. Barriers to, and opportunities for, palliative care development in the Eastern Mediterranean Region. Lancet Oncol. 2017;18(3):e176-e84. PMID 28271872.

【JAMA. 2017;317(8-20)】
8.米国の1980〜2014年のがん死亡率の推移

Mokdad AH, Dwyer-Lindgren L, Fitzmaurice C, Stubbs RW, Bertozzi-Villa A, Morozoff C, et al. Trends and Patterns of Disparities in Cancer Mortality Among US Counties, 1980-2014. JAMA. 2017;317(4):388-406. PMID 28118455.
9.限局型前立腺がんの治療後3年後の患者報告アウトカムPRO
Barocas DA, Alvarez J, Resnick MJ, Koyama T, Hoffman KE, Tyson MD, et al. Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient-Reported Outcomes After 3 Years. JAMA. 2017;317(11):1126-40. PMID 28324093.
10.限局型前立腺がんでの治療間でのQOLの比較
Chen RC, Basak R, Meyer AM, Kuo TM, Carpenter WR, Agans RP, et al. Association Between Choice of Radical Prostatectomy, External Beam Radiotherapy, Brachytherapy, or Active Surveillance and Patient-Reported Quality of Life Among Men With Localized Prostate Cancer. JAMA. 2017;317(11):1141-50. PMID 28324092.
11.術後のオピオイド処方と痛み評価(Letter)
Lee JS, Hu HM, Brummett CM, Syrjamaki JD, Dupree JM, Englesbe MJ, et al. Postoperative Opioid Prescribing and the Pain Scores on Hospital Consumer Assessment of Healthcare Providers and Systems Survey. JAMA. 2017;317(19):2013-5. PMID 28510669.
12.高齢者のうつ病治療のレビュー
Kok RM, Reynolds CF, 3rd. Management of Depression in Older Adults: A Review. JAMA. 2017;317(20):2114-22. PMID 28535241.

【JAMA Intern Med. 2017;177(3-5)】
13.米国の不法移民のホスピス利用

Gray NA, Boucher NA, Kuchibhatla M, Johnson KS. Hospice Access for Undocumented Immigrants. JAMA Intern Med. 2017;177(4):579-80. PMID 28166315.

【BMJ. 2017;354(8095-8107)】
14.オピオイド鎮痛薬とベンゾジアゼピンの併用処方と過量摂取の関連

Sun EC, Dixit A, Humphreys K, Darnall BD, Baker LC, Mackey S. Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis. BMJ. 2017;356:j760. PMID 28292769.
15.オピオイド依存に対するメサドンまたはブプレノルフィン代替療法の死亡率のレビュー
Sordo L, Barrio G, Bravo MJ, Indave BI, Degenhardt L, Wiessing L, et al. Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies. BMJ. 2017;357:j1550. PMID 28446428.
16.悲嘆の総説(Practice)
Boelen PA, Smid GE. Disturbed grief: prolonged grief disorder and persistent complex bereavement disorder. BMJ. 2017;357:j2016. PMID 28522468.

【Ann Intern Med. 2017;166(5-10)】
17.肥満とホスピス利用の関連

Harris JA, Byhoff E, Perumalswami CR, Langa KM, Wright AA, Griggs JJ. The Relationship of Obesity to Hospice Use and Expenditures: A Cohort Study. Ann Intern Med. 2017;166(6):381-9. PMID 28166546.
18.腰痛の薬物療法のレビューと米国内科学会のガイドライン
Chou R, Deyo R, Friedly J, Skelly A, Weimer M, Fu R, et al. Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline. Ann Intern Med. 2017;166(7):480-92. PMID 28192790.
19.腰痛の非薬物療法のレビューと米国内科学会のガイドライン
Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, et al. Nonpharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline. Ann Intern Med. 2017;166(7):493-505. PMID 28192793.
20.急性・亜急性・慢性腰痛の非侵襲的治療のレビューと米国内科学会のガイドライン
Qaseem A, Wilt TJ, McLean RM, Forciea MA, Clinical Guidelines Committee of the American College of P. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2017;166(7):514-30. PMID 28192789.
21.薬物依存の予防と治療:米国内科学会ポジションペーパー
Crowley R, Kirschner N, Dunn AS, Bornstein SS, Health, Public Policy Committee of the American College of P. Health and Public Policy to Facilitate Effective Prevention and Treatment of Substance Use Disorders Involving Illicit and Prescription Drugs: An American College of Physicians Position Paper. Ann Intern Med. 2017;166(10):733-6. PMID 28346947.

【J Clin Oncol. 2017;35(7-15)】
22.フェンタニル舌下錠とモルヒネ皮下注射のレスキュー投与の比較:オピオイド治療中の重度の痛みでのRCT

Zecca E, Brunelli C, Centurioni F, Manzoni A, Pigni A, Caraceni A. Fentanyl Sublingual Tablets Versus Subcutaneous Morphine for the Management of Severe Cancer Pain Episodes in Patients Receiving Opioid Treatment: A Double-Blind, Randomized, Noninferiority Trial. J Clin Oncol. 2017;35(7):759-65. PMID 28113021.
23.高齢がん患者の虚弱分類指標による予後予測
Ferrat E, Paillaud E, Caillet P, Laurent M, Tournigand C, Lagrange JL, et al. Performance of Four Frailty Classifications in Older Patients With Cancer: Prospective Elderly Cancer Patients Cohort Study. J Clin Oncol. 2017;35(7):766-77. PMID 28095145.
24.進行期肺がん・消化器がんでの早期緩和ケア介入のRCT
Temel JS, Greer JA, El-Jawahri A, Pirl WF, Park ER, Jackson VA, et al. Effects of Early Integrated Palliative Care in Patients With Lung and GI Cancer: A Randomized Clinical Trial. J Clin Oncol. 2017;35(8):834-41. PMID 28029308.
25.進行がんでの終末期ディスカッションに対する医療者のコーチング訓練と質問促進リストのクラスターRCT
Rodenbach RA, Brandes K, Fiscella K, Kravitz RL, Butow PN, Walczak A, et al. Promoting End-of-Life Discussions in Advanced Cancer: Effects of Patient Coaching and Question Prompt Lists. J Clin Oncol. 2017;35(8):842-51. PMID 28135140.
26.成人がんサバイバーでの心機能障害の予防とモニタリング:米国腫瘍学会のガイドライン
Armenian SH, Lacchetti C, Barac A, Carver J, Constine LS, Denduluri N, et al. Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. 2017;35(8):893-911. PMID 27918725.
27.乳がんサバイバーの性機能に対するインターネットによる認知行動療法のRCT
Hummel SB, van Lankveld J, Oldenburg HSA, Hahn DEE, Kieffer JM, Gerritsma MA, et al. Efficacy of Internet-Based Cognitive Behavioral Therapy in Improving Sexual Functioning of Breast Cancer Survivors: Results of a Randomized Controlled Trial. J Clin Oncol. 2017;35(12):1328-40. PMID 28240966.
28.小児がんでの頭蓋内放射線治療後の髄膜腫の長期リスク
Bowers DC, Moskowitz CS, Chou JF, Mazewski CM, Neglia JP, Armstrong GT, et al. Morbidity and Mortality Associated With Meningioma After Cranial Radiotherapy: A Report From the Childhood Cancer Survivor Study. J Clin Oncol. 2017;35(14):1570-6. PMID 28339329.
29.小児・若年がんサバイバーの生殖:スウェーデンの大規模コホート
Armuand G, Skoog-Svanberg A, Bladh M, Sydsjo G. Reproductive Patterns Among Childhood and Adolescent Cancer Survivors in Sweden: A Population-Based Matched-Cohort Study. J Clin Oncol. 2017;35(14):1577-83. PMID 28350518.
30.頭頚部がんサバイバー・ケア:米国腫瘍学会のガイドライン
Nekhlyudov L, Lacchetti C, Davis NB, Garvey TQ, Goldstein DP, Nunnink JC, et al. Head and Neck Cancer Survivorship Care Guideline: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Cancer Society Guideline. J Clin Oncol. 2017;35(14):1606-21. PMID 28240970.
31.乳がん術後の持続性疼痛の予測モデル
Meretoja TJ, Andersen KG, Bruce J, Haasio L, Sipila R, Scott NW, et al. Clinical Prediction Model and Tool for Assessing Risk of Persistent Pain After Breast Cancer Surgery. J Clin Oncol. 2017;35(15):1660-7. PMID 28524782.

【Ann Oncol. 2017;28(3-5)】
32.大腸がんでの緩和的化学療法の重度の有害事象とQOLとの関連のレビュー

Schuurhuizen C, Braamse AMJ, Konings I, Sprangers MAG, Ket JCF, Dekker J, et al. Does severe toxicity affect global quality of life in patients with metastatic colorectal cancer during palliative systemic treatment? A systematic review. Ann Oncol. 2017;28(3):478-86. PMID 27998965.
33.腎がん治療後の二次発がんリスク
Rombouts AJM, Hugen N, Elferink MAG, Feuth T, Poortmans PMP, Nagtegaal ID, et al. Incidence of second tumors after treatment with or without radiation for rectal cancer. Ann Oncol. 2017;28(3):535-40. PMID 27993790.
34.アントラサイクリン系薬剤による心筋症の予防介入のレビュー
Abdel-Qadir H, Ong G, Fazelzad R, Amir E, Lee DS, Thavendiranathan P, et al. Interventions for preventing cardiomyopathy due to anthracyclines: a Bayesian network meta-analysis. Ann Oncol. 2017;28(3):628-33. PMID 28028033.
35.死亡前の化学療法の関連要因
Rochigneux P, Raoul JL, Beaussant Y, Aubry R, Goldwasser F, Tournigand C, et al. Use of chemotherapy near the end of life: what factors matter? Ann Oncol. 2017;28(4):809-17. PMID 27993817.
36.がん患者の主観的・客観的な味覚・嗅覚の変化のレビュー
Spotten LE, Corish CA, Lorton CM, Ui Dhuibhir PM, O'Donoghue NC, O'Connor B, et al. Subjective and objective taste and smell changes in cancer. Ann Oncol. 2017;28(5):969-84. PMID 28327968.

【Eur J Cancer. 2017;73-78】
37.終末期の治療選択での意思決定の後悔モデル
Tsalatsanis A, Hozo I, Djulbegovic B. Acceptable regret model in the end-of-life setting: Patients require high level of certainty before forgoing management recommendations. Eur J Cancer. 2017;75:159-66. PMID 28235727.
38.化学療法中のインフルエンザワクチン
Vollaard A, Schreuder I, Slok-Raijmakers L, Opstelten W, Rimmelzwaan G, Gelderblom H. Influenza vaccination in adult patients with solid tumours treated with chemotherapy. Eur J Cancer. 2017;76:134-43. PMID 28324748.
39.転移性食道がんでの病院の治療実績と予後の関連
Haj Mohammad N, Bernards N, van Putten M, Lemmens V, van Oijen MGH, van Laarhoven HWM. Volume-outcome relation in palliative systemic treatment of metastatic oesophagogastric cancer. Eur J Cancer. 2017;78:28-36. PMID 28412586.
40.中咽頭がん患者のQOLのメタアナリシス
Hoxbroe Michaelsen S, Gronhoj C, Hoxbroe Michaelsen J, Friborg J, von Buchwald C. Quality of life in survivors of oropharyngeal cancer: A systematic review and meta-analysis of 1366 patients. Eur J Cancer. 2017;78:91-102. PMID 28431302.

【Br J Cancer. 2017;116(5-10)】
41.がん関連倦怠感に対する患者教育のRCT

Bourmaud A, Anota A, Moncharmont C, Tinquaut F, Oriol M, Trillet-Lenoir V, et al. Cancer-related fatigue management: evaluation of a patient education program with a large-scale randomised controlled trial, the PEPs fatigue study. Br J Cancer. 2017;116(7):849-58. PMID 28196066.
42.前立腺がん治療5年後の機能障害
Lehto US, Tenhola H, Taari K, Aromaa A. Patients' perceptions of the negative effects following different prostate cancer treatments and the impact on psychological well-being: a nationwide survey. Br J Cancer. 2017;116(7):864-73. PMID 28222069.
43.肺塞栓症のリスク因子
Carmona-Bayonas A, Jimenez-Fonseca P, Font C, Fenoy F, Otero R, Beato C, et al. Predicting serious complications in patients with cancer and pulmonary embolism using decision tree modelling: the EPIPHANY Index. Br J Cancer. 2017;116(8):994-1001. PMID 28267709.

【Cancer. 2017;123(5-10)】
44.神経膠芽腫の予後と家族の統制感との関連
Boele FW, Given CW, Given BA, Donovan HS, Schulz R, Weimer JM, et al. Family caregivers' level of mastery predicts survival of patients with glioblastoma: A preliminary report. Cancer. 2017;123(5):832-40. PMID 27787881.
45.殺細胞性抗がん剤治療中のインフルエンザワクチン接種のタイミング
Keam B, Kim MK, Choi Y, Choi SJ, Choe PG, Lee KH, et al. Optimal timing of influenza vaccination during 3-week cytotoxic chemotherapy cycles. Cancer. 2017;123(5):841-8. PMID 27997703.
46.米国の先住民族の乳がんサバイバーの治療とQOL
Goodwin EA, Burhansstipanov L, Dignan M, Jones KL, Kaur JS. The experience of treatment barriers and their influence on quality of life in American Indian/Alaska Native breast cancer survivors. Cancer. 2017;123(5):861-8. PMID 27763688.
47.米国のAYA世代がん患者での精神的苦痛と医療利用
Kaul S, Avila JC, Mutambudzi M, Russell H, Kirchhoff AC, Schwartz CL. Mental distress and health care use among survivors of adolescent and young adult cancer: A cross-sectional analysis of the National Health Interview Survey. Cancer. 2017;123(5):869-78. PMID 27859009.
48.がん医療での医療費のコミュニケーションのレビュー
Shih YT, Chien CR. A review of cost communication in oncology: Patient attitude, provider acceptance, and outcome assessment. Cancer. 2017;123(6):928-39. PMID 27893929.
49.前立腺がんでのセカンドオピニオンと治療選択の関連
Radhakrishnan A, Grande D, Mitra N, Bekelman J, Stillson C, Pollack CE. Second opinions from urologists for prostate cancer: Who gets them, why, and their link to treatment. Cancer. 2017;123(6):1027-34. PMID 28263389.
50.がん診断前のアルコール消費量と大腸がんの予後との関連
Phipps AI, Robinson JR, Campbell PT, Win AK, Figueiredo JC, Lindor NM, et al. Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry. Cancer. 2017;123(6):1035-43. PMID 27861761.
51.硬膜外転移の診断と治療
Yanez ML, Miller JJ, Batchelor TT. Diagnosis and treatment of epidural metastases. Cancer. 2017;123(7):1106-14. PMID 28026861.
52.がん診断後のソーシャルネットワークと乳がんの予後
Kroenke CH, Michael YL, Poole EM, Kwan ML, Nechuta S, Leas E, et al. Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project. Cancer. 2017;123(7):1228-37. PMID 27943274.
53.小児がんによる就業への短期・長期的な影響
Lindahl Norberg A, Montgomery SM, Bottai M, Heyman M, Hoven EI. Short-term and long-term effects of childhood cancer on income from employment and employment status: A national cohort study in Sweden. Cancer. 2017;123(7):1238-48. PMID 27870013.
54.がんサバイバーの運動療法のRCT
Irwin ML, Cartmel B, Harrigan M, Li F, Sanft T, Shockro L, et al. Effect of the LIVESTRONG at the YMCA exercise program on physical activity, fitness, quality of life, and fatigue in cancer survivors. Cancer. 2017;123(7):1249-58. PMID 27893938.
55.造血幹細胞移植レシピエントのがんと治療関連の苦痛の経時変化
Syrjala KL, Sutton SK, Jim HS, Knight JM, Wood WA, Lee SJ, et al. Cancer and treatment distress psychometric evaluation over time: A BMT CTN 0902 secondary analysis. Cancer. 2017;123(8):1416-23. PMID 27893933.
56.乳がん再発の恐怖に対する認知バイアス調整アプローチのRCT
Lichtenthal WG, Corner GW, Slivjak ET, Roberts KE, Li Y, Breitbart W, et al. A pilot randomized controlled trial of cognitive bias modification to reduce fear of breast cancer recurrence. Cancer. 2017;123(8):1424-33. PMID 28055119.
57.PSを用いた予後予測指標の精度の比較
Yamada T, Morita T, Maeda I, Inoue S, Ikenaga M, Matsumoto Y, et al. A prospective, multicenter cohort study to validate a simple performance status-based survival prediction system for oncologists. Cancer. 2017;123(8):1442-52. PMID 27926777.
58.米国のがんサバイバーの経済的理由による処方薬の変化
Zheng Z, Han X, Guy GP, Jr., Davidoff AJ, Li C, Banegas MP, et al. Do cancer survivors change their prescription drug use for financial reasons? Findings from a nationally representative sample in the United States. Cancer. 2017;123(8):1453-63. PMID 28218801.
59.小児がんの影響に関する成人サバイバーの認識
Willard VW, Klosky JL, Li C, Srivastava DK, Brinkman TM, Robison LL, et al. The impact of childhood cancer: Perceptions of adult survivors. Cancer. 2017;123(9):1625-34. PMID 28098955.
60.喉頭摘出後の有害事象・在院日数・再入院
Goepfert RP, Hutcheson KA, Lewin JS, Desai NG, Zafereo ME, Hessel AC, et al. Complications, hospital length of stay, and readmission after total laryngectomy. Cancer. 2017;123(10):1760-7. PMID 28026864.
61.早期乳がんの補助化学療法中の倦怠感のマーカー
Mortimer JE, Waliany S, Dieli-Conwright CM, Patel SK, Hurria A, Chao J, et al. Objective physical and mental markers of self-reported fatigue in women undergoing (neo)adjuvant chemotherapy for early-stage breast cancer. Cancer. 2017;123(10):1810-6. PMID 28061004.
62.造血幹細胞移植前の抑うつと移植後アウトカムの関連
El-Jawahri A, Chen YB, Brazauskas R, He N, Lee SJ, Knight JM, et al. Impact of pre-transplant depression on outcomes of allogeneic and autologous hematopoietic stem cell transplantation. Cancer. 2017;123(10):1828-38. PMID 28102896.
63.患者報告アウトカムと早期大腸がんの予後の関連
Hsu T, Speers CH, Kennecke HF, Cheung WY. The utility of abbreviated patient-reported outcomes for predicting survival in early stage colorectal cancer. Cancer. 2017;123(10):1839-47. PMID 28081292.
64.患者報告アウトカムの示し方の違いによる解釈しやすさ
Snyder CF, Smith KC, Bantug ET, Tolbert EE, Blackford AL, Brundage MD, et al. What do these scores mean? Presenting patient-reported outcomes data to patients and clinicians to improve interpretability. Cancer. 2017;123(10):1848-59. PMID 28085201.
65.消化器がんサバイバーの患者報告アウトカム
Frick MA, Vachani CC, Hampshire MK, Bach C, Arnold-Korzeniowski K, Metz JM, et al. Survivorship after lower gastrointestinal cancer: Patient-reported outcomes and planning for care. Cancer. 2017;123(10):1860-8. PMID 28055110.
66.小児がん長期サバイバーの性的心理の発達への治療の影響
Lehmann V, Tuinman MA, Keim MC, Winning AM, Olshefski RS, Bajwa RPS, et al. Psychosexual development and satisfaction in long-term survivors of childhood cancer: Neurotoxic treatment intensity as a risk indicator. Cancer. 2017;123(10):1869-76. PMID 28165611.

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