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Japanese Society for Palliative Medicine
News Letter No.75
日本緩和医療学会ニューズレター
May 2017  75
Journal Watch
緩和ケアに関する論文レビュー
名古屋大学大学院 医学系研究科 看護学専攻 基礎・臨床看護学講座  佐藤 一樹
対象雑誌:N Engl J Med, Lancet, Lancet Oncol, JAMA, JAMA Intern Med, BMJ, Ann Intern Med, J Clin Oncol, Ann Oncol, Eur J Cancer, Br J Cancer, Cancer

対象期間:2016年12月〜2017年2月刊行分

いわゆる“トップジャーナル”に掲載された緩和ケアに関する最新論文を広く紹介します。

【N Engl J Med. 2016;375(22-26), 2017;376(1-8)】
1.米国の救急医のオピオイド処方

Barnett ML, Olenski AR, Jena AB. Opioid-Prescribing Patterns of Emergency Physicians and Risk of Long-Term Use. N Engl J Med. 2017;376(7):663-73. PMID 28199807.

【Lancet. 2016;388(10061-10063), 2017;389(10064-10071)】
なし

【Lancet Oncol. 2016;17(12), 2017;18(1-2)】
2.小児・若年男性がん長期サバイバーのケアガイドライン

Skinner R, Mulder RL, Kremer LC, Hudson MM, Constine LS, Bardi E, et al. Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium. Lancet Oncol. 2017;18(2):e75-e90. PMID 28214419.
3.小児脳腫瘍サバイバーの放射線治療による認知機能障害
Ajithkumar T, Price S, Horan G, Burke A, Jefferies S. Prevention of radiotherapy-induced neurocognitive dysfunction in survivors of paediatric brain tumours: the potential role of modern imaging and radiotherapy techniques. Lancet Oncol. 2017;18(2):e91-e100. PMID 28214420.

【JAMA.2016;316(21-24), 2017;317(1-7)】
4.研修医の異動による入院患者の死亡リスク増加

Golub RM. Looking Inward and Reflecting Back: Medical Education and JAMA. JAMA. 2016;316(21):2200-3. PMID 27923079.
5.主要死因別死亡率:米国の1980〜2014年の統計
Dwyer-Lindgren L, Bertozzi-Villa A, Stubbs RW, Morozoff C, Kutz MJ, Huynh C, et al. US County-Level Trends in Mortality Rates for Major Causes of Death, 1980-2014. JAMA. 2016;316(22):2385-401. PMID 27959996.
6.骨転移の骨イベントに対するゾレドロン酸の投与間隔のRCT
Himelstein AL, Foster JC, Khatcheressian JL, Roberts JD, Seisler DK, Novotny PJ, et al. Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial. JAMA. 2017;317(1):48-58. PMID 28030702.
7.敗血症の新診断基準Sepsis-3は院内死亡率を予測する
Freund Y, Lemachatti N, Krastinova E, Van Laer M, Claessens YE, Avondo A, et al. Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department. JAMA. 2017;317(3):301-8. PMID 28114554.
8.がん死亡率の格差:米国の1980〜2014年の統計
Mokdad AH, Dwyer-Lindgren L, Fitzmaurice C, Stubbs RW, Bertozzi-Villa A, Morozoff C, et al. Trends and Patterns of Disparities in Cancer Mortality Among US Counties, 1980-2014. JAMA. 2017;317(4):388-406. PMID 28118455.
9.乳がん化学療法での脱毛に対する頭皮冷却のRCT
Nangia J, Wang T, Osborne C, Niravath P, Otte K, Papish S, et al. Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial. JAMA. 2017;317(6):596-605. PMID 28196254.
10.乳がん化学療法での脱毛と頭皮冷却の関連
Rugo HS, Klein P, Melin SA, Hurvitz SA, Melisko ME, Moore A, et al. Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer. JAMA. 2017;317(6):606-14. PMID 28196257.
11.慢性腰痛に対するマインドフルネスストレス逓減法の長期効果に関するRCT(短報)
Cherkin DC, Anderson ML, Sherman KJ, Balderson BH, Cook AJ, Hansen KE, et al. Two-Year Follow-up of a Randomized Clinical Trial of Mindfulness-Based Stress Reduction vs Cognitive Behavioral Therapy or Usual Care for Chronic Low Back Pain. JAMA. 2017;317(6):642-4. PMID 28196244.
12.高齢者の抑うつに対する多職種ケアのRCT
Gilbody S, Lewis H, Adamson J, Atherton K, Bailey D, Birtwistle J, et al. Effect of Collaborative Care vs Usual Care on Depressive Symptoms in Older Adults With Subthreshold Depression: The CASPER Randomized Clinical Trial. JAMA. 2017;317(7):728-37. PMID 28241357.
13.小児がんの治療と二次発がんリスク: 1970〜2015 年の統計データ
Turcotte LM, Liu Q, Yasui Y, Arnold MA, Hammond S, Howell RM, et al. Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015. JAMA. 2017;317(8):814-24. PMID 28245323.

【JAMA Intern Med. 2016;176(12), 2017;177(1-2)】
14.外来医療の質:米国の2002〜2013年の調査

Levine DM, Linder JA, Landon BE. The Quality of Outpatient Care Delivered to Adults in the United States, 2002 to 2013. JAMA Intern Med. 2016;176(12):1778-90. PMID 27749962.
15.米国の州別の喫煙率とがん死亡率の地域相関研究
Lortet-Tieulent J, Goding Sauer A, Siegel RL, Miller KD, Islami F, Fedewa SA, et al. State-Level Cancer Mortality Attributable to Cigarette Smoking in the United States. JAMA Intern Med. 2016;176(12):1792-8. PMID 27775761.
16.米国のナーシングホームの進行認知症高齢者での人工呼吸器使用とICU病床数の関連
Teno JM, Gozalo P, Khandelwal N, Curtis JR, Meltzer D, Engelberg R, et al. Association of Increasing Use of Mechanical Ventilation Among Nursing Home Residents With Advanced Dementia and Intensive Care Unit Beds. JAMA Intern Med. 2016;176(12):1809-16. PMID 27723891.
17.進行認知症での意思決定支援Goals of Care介入のRCT
Hanson LC, Zimmerman S, Song MK, Lin FC, Rosemond C, Carey TS, et al. Effect of the Goals of Care Intervention for Advanced Dementia: A Randomized Clinical Trial. JAMA Intern Med. 2017;177(1):24-31. PMID 27893884.
18.せん妄に対する経口リスペリドンとハロペリドールのRCT
Agar MR, Lawlor PG, Quinn S, Draper B, Caplan GA, Rowett D, et al. Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care: A Randomized Clinical Trial. JAMA Intern Med. 2017;177(1):34-42. PMID 27918778.
19.医師のバーンアウトに対する介入試験のシステマティックレビュー
Panagioti M, Panagopoulou E, Bower P, Lewith G, Kontopantelis E, Chew-Graham C, et al. Controlled Interventions to Reduce Burnout in Physicians: A Systematic Review and Meta-analysis. JAMA Intern Med. 2017;177(2):195-205. PMID 27918798.
20.医師の性別と高齢患者の入院死亡率と再入院率との関連
Tsugawa Y, Jena AB, Figueroa JF, Orav EJ, Blumenthal DM, Jha AK. Comparison of Hospital Mortality and Readmission Rates for Medicare Patients Treated by Male vs Female Physicians. JAMA Intern Med. 2017;177(2):206-13. PMID 27992617.

【BMJ. 2016;353(8084-8086), 2017;354(8087-8094】
21.大腸がんでのアスピリン以外のNSAIDsと再発の関連

Dulai PS, Singh S, Marquez E, Khera R, Prokop LJ, Limburg PJ, et al. Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis. BMJ. 2016;355:i6188. PMID 27919915.
22.心疾患イベントの低リスク患者でのコミュニケーションスキルのRCT
Hess EP, Hollander JE, Schaffer JT, Kline JA, Torres CA, Diercks DB, et al. Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial. BMJ. 2016;355:i6165. PMID 27919865.
23.抑うつとがん死亡の関連
Batty GD, Russ TC, Stamatakis E, Kivimaki M. Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies. BMJ. 2017;356:j108. PMID 28122812.

【Ann Intern Med. 2016;165(11-12), 2017;166(1-4)】
24.重度の機能性便秘に対する針治療のRCT

Liu Z, Yan S, Wu J, He L, Li N, Dong G, et al. Acupuncture for Chronic Severe Functional Constipation: A Randomized Trial. Ann Intern Med. 2016;165(11):761-9. PMID 27618593.
25.時代や治療内容ごとの小児がん患者のQOL
Ness KK, Hudson MM, Jones KE, Leisenring W, Yasui Y, Chen Y, et al. Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors. Ann Intern Med. 2017;166(2):89-98. PMID 27820947.
26.オピオイド関連障害に対する一般診療所での治療モデルのレビュー
Korthuis PT, McCarty D, Weimer M, Bougatsos C, Blazina I, Zakher B, et al. Primary Care-Based Models for the Treatment of Opioid Use Disorder: A Scoping Review. Ann Intern Med. 2017;166(4):268-78. PMID 27919103.

【J Clin Oncol. 2016;34(34-36), 2017;35(1-6)】
27.ホジキンリンパ腫でのがん関連倦怠感と治療効果や社会性との関連

Behringer K, Goergen H, Muller H, Thielen I, Brillant C, Kreissl S, et al. Cancer-Related Fatigue in Patients With and Survivors of Hodgkin Lymphoma: The Impact on Treatment Outcome and Social Reintegration. J Clin Oncol. 2016;34(36):4329-37. PMID 27998235.
28.再発リスクの高い悪性黒色腫患者の死の恐怖に対する心理教育的介入のRCT
Dieng M, Butow PN, Costa DS, Morton RL, Menzies SW, Mireskandari S, et al. Psychoeducational Intervention to Reduce Fear of Cancer Recurrence in People at High Risk of Developing Another Primary Melanoma: Results of a Randomized Controlled Trial. J Clin Oncol. 2016;34(36):4405-14. PMID 27998215.
29.米国のがんサバイバーでの抗不安薬・抗うつ薬の使用状況
Hawkins NA, Soman A, Buchanan Lunsford N, Leadbetter S, Rodriguez JL. Use of Medications for Treating Anxiety and Depression in Cancer Survivors in the United States. J Clin Oncol. 2017;35(1):78-85. PMID 28034075.
30.早期緩和ケアに関するASCOガイドラインの更新
Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, et al. Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2017;35(1):96-112. PMID 28034065.
31.化学療法後の認知機能低下に対するWebによる認知リハビリテーションの効果
Bray VJ, Dhillon HM, Bell ML, Kabourakis M, Fiero MH, Yip D, et al. Evaluation of a Web-Based Cognitive Rehabilitation Program in Cancer Survivors Reporting Cognitive Symptoms After Chemotherapy. J Clin Oncol. 2017;35(2):217-25. PMID 28056205.
32.カナダ・オンタリオ州の小児がんでの終末期の積極医療の状況とその予測因子
Kassam A, Sutradhar R, Widger K, Rapoport A, Pole JD, Nelson K, et al. Predictors of and Trends in High-Intensity End-of-Life Care Among Children With Cancer: A Population-Based Study Using Health Services Data. J Clin Oncol. 2017;35(2):236-42. PMID 28056201.
33.進行前立腺患者でのマインドフルネスを用いた認知療法のRCT
Chambers SK, Occhipinti S, Foley E, Clutton S, Legg M, Berry M, et al. Mindfulness-Based Cognitive Therapy in Advanced Prostate Cancer: A Randomized Controlled Trial. J Clin Oncol. 2017;35(3):291-7. PMID 27870567.
34.がん患者の受けたホスピスケアと終末期ケアの家族評価との関連
Kumar P, Wright AA, Hatfield LA, Temel JS, Keating NL. Family Perspectives on Hospice Care Experiences of Patients with Cancer. J Clin Oncol. 2017;35(4):432-9. PMID 27992271.
35.乳がん化学療法後の認知機能低下とその関連要因
Janelsins MC, Heckler CE, Peppone LJ, Kamen C, Mustian KM, Mohile SG, et al. Cognitive Complaints in Survivors of Breast Cancer After Chemotherapy Compared With Age-Matched Controls: An Analysis From a Nationwide, Multicenter, Prospective Longitudinal Study. J Clin Oncol. 2017;35(5):506-14. PMID 28029304.
36.多発性骨髄腫での施設の治療件数と死亡率の関連
Go RS, Bartley AC, Crowson CS, Shah ND, Habermann EB, Holton SJ, et al. Association Between Treatment Facility Volume and Mortality of Patients With Multiple Myeloma. J Clin Oncol. 2017;35(6):598-604. PMID 28199819.
37.若年がん患者のQOLの縦断調査
Husson O, Zebrack BJ, Block R, Embry L, Aguilar C, Hayes-Lattin B, et al. Health-Related Quality of Life in Adolescent and Young Adult Patients With Cancer: A Longitudinal Study. J Clin Oncol. 2017;35(6):652-9. PMID 28095151.

【Ann Oncol. 2016;27(12), 2017;28(1-2)】
38.がん患者の経済的問題とQOLや予後との関連

Huntington SF. Cancer-related financial toxicity: beyond the realm of drug pricing and out-of-pocket costs. Ann Oncol. 2016;27(12):2143-5. PMID 27742653.
39.ドイツ語版PRO-CTCAEの開発
Hagelstein V, Ortland I, Wilmer A, Mitchell SA, Jaehde U. Validation of the German patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE?). Ann Oncol. 2016;27(12):2294-9. PMID 27681863.
40.早期緩和ケア介入の進行がん患者の家族に対する効果:クラスターRCT
McDonald J, Swami N, Hannon B, Lo C, Pope A, Oza A, et al. Impact of early palliative care on caregivers of patients with advanced cancer: cluster randomised trial. Ann Oncol. 2017;28(1):163-8. PMID 27687308.
41.米国のがん患者の死因
Zaorsky NG, Churilla TM, Egleston BL, Fisher SG, Ridge JA, Horwitz EM, et al. Causes of death among cancer patients. Ann Oncol. 2017;28(2):400-7. PMID 27831506.

【Eur J Cancer. 2016;69, 2017;70-72】
42.オランダでの化学療法後の末梢神経障害に関連したQOL評価

Mols F, van de Poll-Franse LV, Vreugdenhil G, Beijers AJ, Kieffer JM, Aaronson NK, et al. Reference data of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 Questionnaire in the general Dutch population. Eur J Cancer. 2016;69:28-38. PMID 27814471.
43.大腸がん診断2〜4年後の非雇用リスク
Rottenberg Y, Ratzon NZ, Cohen M, Hubert A, Uziely B, de Boer AG. Unemployment risk at 2 and 4 years following colorectal cancer diagnosis: a population based study. Eur J Cancer. 2016;69:70-6. PMID 27821321.
44.イタリアでの進行膵がんの早期緩和ケア介入のRCTでの終末期の積極医療の比較
Maltoni M, Scarpi E, Dall'Agata M, Schiavon S, Biasini C, Codeca C, et al. Systematic versus on-demand early palliative care: A randomized clinical trial assessing quality of care and treatment aggressiveness near the end of life. Eur J Cancer. 2016;69:110-8. PMID 27821313.
45.悪性黒色腫での代替補完療法の実施状況
Loquai C, Dechent D, Garzarolli M, Kaatz M, Kaehler KC, Kurschat P, et al. Use of complementary and alternative medicine: A multicenter cross-sectional study in 1089 melanoma patients. Eur J Cancer. 2017;71:70-9. PMID 27984769.
46.進行がんの骨転移による痛みに関連したQOL評価の改善y
von Moos R, Costa L, Ripamonti CI, Niepel D, Santini D. Improving quality of life in patients with advanced cancer: Targeting metastatic bone pain. Eur J Cancer. 2017;71:80-94. PMID 27984770.
47.肺がん治療での系統的苦痛スクリーニングと支持療法のRCT
Geerse OP, Hoekstra-Weebers JE, Stokroos MH, Burgerhof JG, Groen HJ, Kerstjens HA, et al. Structural distress screening and supportive care for patients with lung cancer on systemic therapy: A randomised controlled trial. Eur J Cancer. 2017;72:37-45. PMID 28024265.
48.ドイツでの抑うつのがんサバイバーと一般市民の比較
Hartung TJ, Brahler E, Faller H, Harter M, Hinz A, Johansen C, et al. The risk of being depressed is significantly higher in cancer patients than in the general population: Prevalence and severity of depressive symptoms across major cancer types. Eur J Cancer. 2017;72:46-53. PMID 28024266.

【Br J Cancer. 2016;115(11-12), 2017;116(1-4)】
49.乳がんの病的骨折による入院・死亡リスク

Colzani E, Clements M, Johansson AL, Liljegren A, He W, Brand J, et al. Risk of hospitalisation and death due to bone fractures after breast cancer: a registry-based cohort study. Br J Cancer. 2016;115(11):1400-7. PMID 27701383.
50.小児がん死亡のなかでの治療関連死
Pole JD, Gibson P, Ethier MC, Lazor T, Johnston DL, Portwine C, et al. Evaluation of treatment-related mortality among paediatric cancer deaths: a population based analysis. Br J Cancer. 2017;116(4):540-5. PMID 28095399.

【Cancer. 2016;122(23-24), 2017;123(1-4)】
51.乳がんの病的骨折による入院・死亡リスク

Colzani E, Clements M, Johansson AL, Liljegren A, He W, Brand J, et al. Risk of hospitalisation and death due to bone fractures after breast cancer: a registry-based cohort study. Br J Cancer. 2016;115(11):1400-7. PMID 27701383.
52.腫瘍医の悲嘆反応とバーンアウトの性差
Granek L, Krzyzanowska MK, Nakash O, Cohen M, Ariad S, Barbera L, et al. Gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists. Cancer. 2016;122(23):3705-14. PMID 27509210.
53.外来での進行がん患者の慢性的なオピオイド使用の頻度と予測因子と尿検査初見
Arthur JA, Edwards T, Lu Z, Reddy S, Hui D, Wu J, et al. Frequency, predictors, and outcomes of urine drug testing among patients with advanced cancer on chronic opioid therapy at an outpatient supportive care clinic. Cancer. 2016;122(23):3732-9. PMID 27509305.
54.若年がん患者の経済的自立度
Gunnes MW, Lie RT, Bjorge T, Syse A, Ruud E, Wesenberg F, et al. Economic independence in survivors of cancer diagnosed at a young age: A Norwegian national cohort study. Cancer. 2016;122(24):3873-82. PMID 27518040.
55.がん診断後のセクシャリティ
Jackson SE, Wardle J, Steptoe A, Fisher A. Sexuality after a cancer diagnosis: A population-based study. Cancer. 2016;122(24):3883-91. PMID 27531631.
56.患者による症状・機能評価PROMISの反応性
Jensen RE, Moinpour CM, Potosky AL, Lobo T, Hahn EA, Hays RD, et al. Responsiveness of 8 Patient-Reported Outcomes Measurement Information System (PROMIS) measures in a large, community-based cancer study cohort. Cancer. 2017;123(2):327-35. PMID 27696377.
57.死亡前 1 年間のがん患者の医療とその要因
Halpern MT, Urato MP, Kent EE. The health care experience of patients with cancer during the last year of life: Analysis of the SEER-CAHPS data set. Cancer. 2017;123(2):336-44. PMID 27654842.
58.小児がん患者の親と医師の困難な関係性に関する質的研究
Mack JW, Ilowite M, Taddei S. Difficult relationships between parents and physicians of children with cancer: A qualitative study of parent and physician perspectives. Cancer. 2017;123(4):675-81. PMID 27727442.

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